Scientists Reconstruct Human Chorion Emergence Using Hippo Pathway Modulation
A human stem cell model using LATS kinase inhibition reconstructs the emergence and three-dimensional self-organization of the human chorion without ...
Tag: Wnt signalling
Viral RNAi Suppressor Unlocks Sterile Beetle Knockdowns and Resolves Axis Formation Debate
A transgenic viral suppressor of RNAi rescues the sterility caused by gene knockdown in red flour beetles, enabling experiments that ...
Lab-grown tumour assembloids reveal why kidney cancers respond differently to immunotherapy
Engineered renal cancer assembloids reveal a tumour–fibroblast–T cell signalling axis that governs stem-like CD8+ T cell maintenance and heterogeneous responses ...
Tumour suppressor gene loss sparks childhood brain tumour in mice, revealing hidden driver
New mouse experiments show that losing the tumour suppressor Apc in pituitary stem cells is enough to cause adamantinomatous craniopharyngioma ...
Flatworm Study Shows β-catenin1 Silencing Halts Tail Regrowth but Fails to Trigger Head Regeneration
Silencing β-catenin1 in the flatworm Macrostomum lignano blocks tail regeneration and blastema formation, but unlike in planarians it never induces ...
Monocytes, Not T Cells, Show Strongest Gene Disruption in Multiple Sclerosis
A reanalysis of bulk RNA-sequencing data from multiple sclerosis patients finds that CD14+ monocytes show the most extensive transcriptional and ...
Young livers heal fast but scar faster: review maps pediatric liver fibrosis pathways
A narrative review in BMC Pediatrics examines how the balance between regeneration and scarring breaks down in pediatric liver fibrosis, ...
Research report: MicroRNA profiling of filtering and non-filtering regions of human trabecular meshwork: changes with ageing and in glaucoma
Human donor tissue showed regional, age-related and glaucoma-associated microRNA patterns in the trabecular meshwork, identifying seven validated candidates while leaving ...
Reprogramming Patient Cells Reveals a Reversible Signalling Flaw Behind a Childhood Hip Disease
A patient-derived stem cell model shows that hyperactive GSK3 signalling suppresses bone, fat and cartilage differentiation in Legg-Calvé-Perthes disease, and ...
Oral Wnt-blocking pill plus lenvatinib shows promise in endometrial cancer after immunotherapy fails
A phase 1b/2 trial found that the oral CBP–β-catenin inhibitor E7386 combined with lenvatinib produced durable responses in advanced endometrial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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