Synthetic enzyme redirects metabolism and slows melanoma xenografts
A synthetic enzyme produced pyruvate inside cancer-cell mitochondria, increased oxidative metabolism, altered growth-related gene expression and slowed human melanoma xenografts ...
Tag: Warburg effect
Epigenetics and Metabolism: The Two-Way Conversation Driving Liver Cancer
A new review in the Chinese Medical Journal maps how epigenetic modifications and metabolic reprogramming fuel each other in hepatocellular ...
Cancer Cells Burn Energy on Futile Transcription by Shifting Their Genetic Start Lines
New research shows that cancer cells universally deregulate transcription start site selection, wasting energy on futile upstream transcription while protecting ...
Cancer Cells Run on a Metabolic Hybrid Engine, and Surgeons May Soon Map It
A new review argues that cancer cells toggle between glycolysis and mitochondrial respiration in hybrid metabolic states, and that mapping ...
Lactate Marks on Histones Drive Wilms Tumor Growth Through a Self-Reinforcing Genetic Loop
New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of ...
Long Noncoding RNA SNHG15 Rewires Liver Cancer Metabolism Through a PDK1-PDHE1α Phosphorylation Switch
A new study shows that the long noncoding RNA SNHG15 drives hepatocellular carcinoma progression by scaffolding the PGK1-PDK1-PDHE1α phosphorylation axis ...
Tumors Steal Fuel and Fuel Inflammation to Starve Head and Neck Cancer Patients
A new review argues that malnutrition in head and neck cancer is driven by tumor metabolism and chronic inflammation rather ...
Blood Metabolites Emerge as Powerful New Signals for Predicting Cancer Outcomes
A new review maps how advances in plasma metabolomics detection technology are turning tumor-driven metabolic fingerprints in blood into tools ...
Single RNA Letter Swap Turns a Thyroid microRNA From Tumor Suppressor Into Cancer Driver
Researchers show that ADAR2-mediated A-to-I RNA editing switches miR-376a-3p from a tumor suppressor to an oncogene in papillary thyroid cancer ...
Ketogenic Diet May Prime the Body to Fight Cancer by Rewiring Metabolism and Immunity
A new review argues that the ketogenic diet may act as a systems-level sensitization platform in cancer therapy by simultaneously ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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