Tag: unfolded protein response

New research in C. elegans reveals that ER-to-Golgi transport proteins actively couple excess cargo to the unfolded protein response in ...

A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could ...

A new review argues that the evolutionarily conserved IRE1α/XBP1 stress-signaling pathway, which governs protein folding, inflammation and insulin action, offers ...

A rat study shows nicotine damages sperm by triggering a maladaptive endoplasmic reticulum stress response driven by oxidative stress, and ...

New research shows that chronic IRE1α-mediated endoplasmic reticulum stress simultaneously boosts melanin production and impairs pigment clearance, explaining why solar ...

Silencing the anti-apoptotic protein Lifeguard in triple-negative breast cancer cells alters intracellular calcium levels and reshapes the expression of endoplasmic ...

A synthetic guaianolide dimer derived from a plant sesquiterpenoid selectively covalently binds the ER chaperone GRP94 at serine 106, triggering ...

New research in Arabidopsis shows that disrupting the mitochondrial calcium uniporter triggers a coordinated unfolded protein response spanning the nucleus, ...

New research identifies the ER-localized cell death regulator BI-1 as a key executor of Arabidopsis resistance to Phytophthora parasitica, controlled ...

A multi-omics Mendelian randomization study links protein folding-related genes PDIA3 and FNIP2 to genetically supported risk of major depressive disorder.