E3 Ligase TRIM37 Steers Cilia Growth by Tagging p62 and Tuning Autophagy
A new study reveals that the E3 ubiquitin ligase TRIM37 regulates primary cilium assembly by ubiquitinating the autophagy receptor p62 ...
Tag: ubiquitination
Common Bile Acid Drug Unlocks a Hidden Human Brake on Radiation-Driven Cancer Immunity
Researchers have identified a human-specific FXR-TRIM22-STAT1 checkpoint that suppresses radiation-induced antitumor immunity, and shown that the clinically approved bile acid ...
Lipoic acid shields pig livers from iron-driven cell death by rewriting protein tags
A new ubiquitylome study shows that dietary alpha-lipoic acid protects pig livers recovering from oxidative stress by boosting ferritin heavy ...
Proteasome Gatekeeper RPT2a Controls When Plants Flower by Destroying a Key Histone Protein
New research reveals that the proteasome subunit RPT2a regulates flowering time in Arabidopsis by promoting the degradation of the chromatin ...
Tiny Micropeptide Blocks Vascular Calcification by Tagging PKM2 for Destruction
A newly identified micropeptide called PKM2 AP inhibits vascular calcification by acting as a molecular glue that triggers ubiquitin-mediated degradation ...
Ubiquitin Enzyme UBE2N Emerges as Master Switch Between Liver Repair and Damage
A new Nature Metabolism study identifies the ubiquitin-conjugating enzyme UBE2N as the molecular switch that determines whether hepatocytes undergo protective ...
Epigenetic Switch That Shields Cartilage From Osteoarthritis Is Revealed
A new study reveals that the epigenetic enzyme DOT1L protects cartilage in osteoarthritis by boosting ITCH expression, which in turn ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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