Scientists Uncover Molecular Switch That Helps Prostate Cancer Spread to Bone
A new study reveals that an AURKA-driven phosphorylation and SUMOylation cascade stabilizes the protein SPICE1, fueling prostate cancer's spread to ...
Tag: ubiquitination
Enzyme USP45 Drives Liver Cancer Growth by Stabilizing Oncoprotein CIAP2
Researchers in China have shown that the deubiquitinating enzyme USP45 promotes hepatocellular carcinoma progression by removing K48-linked ubiquitin chains from ...
Lactate Tags a Tumor Suppressor and Fuels Liver Cancer Growth
Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function ...
How Plants Fine-Tune Their Water Channels to Survive Drought, Salt and Toxic Metals
A new review in Stress Biology details how plants regulate aquaporin water channels through stress-responsive transcription factors and rapid post-translational ...
Chemical Tags on Tiny Vesicles May Shape How Cancer Spreads
A new review in the Journal of Translational Medicine details how post-translational modifications such as ubiquitination, phosphorylation, acetylation, and SUMOylation ...
Hidden Chemical Tags on Proteins and RNA Team Up to Drive Inflammatory Bowel Disease
A new review in the Journal of Translational Medicine details how chemical tags on proteins and RNA interact to control ...
AI Framework Reads the Literature to Map Protein Modifications It Was Never Trained On
Researchers have developed GenPTM, a text-mining framework that extracts protein post-translational modification information from scientific abstracts and generalizes to modification ...
E3 Ligase TRIM37 Steers Cilia Growth by Tagging p62 and Tuning Autophagy
A new study reveals that the E3 ubiquitin ligase TRIM37 regulates primary cilium assembly by ubiquitinating the autophagy receptor p62 ...
Common Bile Acid Drug Unlocks a Hidden Human Brake on Radiation-Driven Cancer Immunity
Researchers have identified a human-specific FXR-TRIM22-STAT1 checkpoint that suppresses radiation-induced antitumor immunity, and shown that the clinically approved bile acid ...
Lipoic acid shields pig livers from iron-driven cell death by rewriting protein tags
A new ubiquitylome study shows that dietary alpha-lipoic acid protects pig livers recovering from oxidative stress by boosting ferritin heavy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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