Tag: ubiquitin-proteasome system

A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...

New research shows that female mice lacking the protein quality-control gene Herc3 suffer faster retinal thinning, greater inflammatory activation, and ...

A new review argues that mammalian cells regulate the construction of their proteasomes through layered transcriptional networks and assembly pathways, ...

Scientists in China have uncovered a microRNA-driven pathway in rice that controls a key antioxidant protein and shapes the plant's ...

New research shows that the microRNA miR-196a clears toxic mutant huntingtin aggregates in Huntington's disease by suppressing Rad23b, a ubiquitin ...

A new review details how the JAMM-family deubiquitinase STAMBPL1 maintains cellular homeostasis and, when overexpressed, drives tumor progression, metastasis, and ...

A new review argues that deubiquitinase enzymes within the ubiquitin-proteasome system offer promising therapeutic angles against KRAS-driven cancers that resist ...

Researchers have cataloged the tomato leaf ubiquitinome four weeks after infection with 'Candidatus Liberibacter solanacearum' haplotypes A and B, revealing ...

Scientists have engineered a PROTAC molecule that destroys the RARα protein and delivered it via Polygonatum sibiricum exosome-like nanoparticles, markedly ...

A new comprehensive review in Discover Chemistry details how PROTACs have evolved from a mechanistic concept into clinically advanced degraders ...