Monovalent Pseudo-Natural Products Boost IDO1 Degradation
In a breakthrough that promises to redefine the landscape of targeted protein degradation, researchers have unveiled a novel class of ...
Tag: ubiquitin-proteasome system
Targeted Protein Degradation: Impacts on Health and Species
In the ever-evolving landscape of biomedical research, targeted protein degradation has emerged as a promising frontier in therapeutic development. This ...
E3 Ligase TRIM7 Accelerates Fatty Liver Disease
A groundbreaking study has unveiled a critical molecular mechanism propelling the progression of non-alcoholic fatty liver disease (NAFLD), one of ...
Targeting the Ubiquitin-Proteasome System to Selectively Degrade LSD1
The persistent overexpression of the lysine-specific demethylase 1 (LSD1) enzyme has been notoriously linked to poor clinical outcomes across a ...
Pellino Ubiquitin Ligases: Dual Roles in Blood Cancers
In the rapidly evolving landscape of cancer research, a new frontier has emerged that sheds light on the critical role ...
Linker-Free PROTACs Drive Efficient Oncoprotein Degradation
In the relentless pursuit to tame the molecular underpinnings of cancer, researchers have long sought innovative methods to target and ...
PVTX-405: Potent Selective IKZF2 Degrader for Immunotherapy
In a groundbreaking advance in cancer immunotherapy, researchers have unveiled PVTX-405, a novel molecular glue degrader that targets IKZF2 with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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