Bibliometric Study Maps Decade of Machine Learning Advances in Lupus Research
A scientometric analysis reveals machine learning studies on systemic lupus erythematosus increased thirtyfold from 2015 to 2025 while identifying persistent ...
Tag: Type I interferon
Excess Type I Interferon Disrupts Lung Development in Trisomy 21
Excess type I interferon signaling disrupts developmental crosstalk and drives lung anomalies associated with Trisomy 21 in developing human lung ...
Type I Interferon-Induced Viperin Promotes Tuberculosis Survival by Inhibiting Macrophage Defenses
A study reveals that type I interferon-induced viperin enables Mycobacterium tuberculosis survival in macrophages by suppressing the protective COX-2, PGE2, ...
JAK Inhibitor Resolves Rare Kidney Complication in Anti-Synthetase Syndrome Case
Clinicians report that targeting the type I interferon pathway with tofacitinib induced complete remission in a patient with treatment-resistant full-house ...
African swine fever virus deploys layered immune evasion that stalls vaccine progress
A new review maps how African swine fever virus dismantles interferon signaling, inflammatory pathways, antigen presentation and lymphocyte function, explaining ...
Blocking One Prolactin Receptor Isoform Selectively Disarms Lupus Immune Cells
Researchers report that a splice-modulating oligomer that reduces the long prolactin receptor isoform lowered pathogenic immune signatures in lupus patients' ...
Liver Survival Protein USP18 Protects Cells From Proteotoxic Stress
A study in mice and liver cells finds that the USP18–STAT2 axis, activated by interferon priming, protects hepatocytes from proteasome-inhibitor-induced ...
Fasting slows colorectal cancer growth in mice by triggering IRF7-driven metabolic and immune changes
A new Cellular Oncology study reports that short-term starvation suppresses colorectal cancer cells by upregulating IRF7, which downregulates PFKFB3, induces ...
Vaccine order matters: mRNA priming with interferon signals boosts mucosal immunity in mice
A mouse study finds that priming with an intramuscular mRNA vaccine before an intranasal adjuvanted booster, through a type I ...
Lab-grown muscle bundles reveal weakness patterns in rare pediatric rheumatic diseases
Engineered three-dimensional muscle bundles grown from pediatric patients with juvenile dermatomyositis, immune-mediated necrotizing myopathy, and arthritis-related weakness show measurable donor-specific ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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