Tag: tumor suppressor

A new study shows that the RNA-binding protein ADAR2 suppresses bladder cancer metastasis by destabilizing FASN mRNA and curbing fatty ...

Researchers report that loss of the tumor suppressor LZTR1 stabilizes mitochondrial transcription factor A, reprogramming liver cancer cells toward complex ...

Researchers report that the tumor-suppressive protein TJP2 stabilizes TIMM21, which boosts SPRY4 and dampens ERK1/2 signaling to restrain clear cell ...

Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function ...

A new study finds that the tumor-suppressive microRNA miR-199a-3p is significantly depleted in breast cancer tissue and that combining its ...

Researchers show that ADAR2-mediated A-to-I RNA editing switches miR-376a-3p from a tumor suppressor to an oncogene in papillary thyroid cancer ...

An integrated single-cell and spatial multi-omics study of glioma identifies the astrocyte-associated gene TTYH1 as a tumor suppressor that impedes ...

A Mount Sinai study published in Science shows that loss of the tumor suppressor p53 reorganizes Wnt signaling into a ...

A new review in Cancer Immunology, Immunotherapy details how EBV-encoded miR-BART4 suppresses the innate immune molecule BPIFB1/LPLUNC1, whose loss promotes ...

Researchers show that the zinc finger protein ZNF154 suppresses bladder cancer by activating PTEN transcription, blocking PI3K/AKT signaling, and triggering ...