Single-Cell Atlas of Glioma Reveals Astrocyte Gene TTYH1 as a Hidden Tumor Suppressor
An integrated single-cell and spatial multi-omics study of glioma identifies the astrocyte-associated gene TTYH1 as a tumor suppressor that impedes ...
Tag: tumor suppressor
How Losing p53 Lets Mutant Cells Colonize Healthy Tissue: A Wnt Gradient Revealed
A Mount Sinai study published in Science shows that loss of the tumor suppressor p53 reorganizes Wnt signaling into a ...
Viral Saboteur Unmasked: How EBV Silences a Key Immune Molecule to Drive Nasopharyngeal Cancer
A new review in Cancer Immunology, Immunotherapy details how EBV-encoded miR-BART4 suppresses the innate immune molecule BPIFB1/LPLUNC1, whose loss promotes ...
Zinc Finger Protein ZNF154 Pushes Bladder Cancer Cells Into Ferroptosis by Suppressing a Key Survival Pathway
Researchers show that the zinc finger protein ZNF154 suppresses bladder cancer by activating PTEN transcription, blocking PI3K/AKT signaling, and triggering ...
Lost Epigenetic Guardian CBX7 Emerges as Key Driver and Drug Target in Glioblastoma
A new review shows that the epigenetic regulator CBX7 acts as a tumor suppressor in glioblastoma, and that restoring its ...
Mitochondrial Enzyme SUCLG2 Emerges as a Tumor Suppressor in Colorectal Cancer
Researchers found that the mitochondrial enzyme SUCLG2 suppresses colorectal cancer by lowering SAM levels to demethylate GADD45G and reactivate p53-mediated ...
RUNX3 Emerges as a Master Switch Behind Cancer Chemoresistance
A new review in Cancer Cell International details how the tumor suppressor RUNX3 regulates apoptosis, drug efflux, cell cycle control, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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