Givinostat blocks colorectal cancer growth by silencing ADAM12 through miR-1938
New research shows the HDAC inhibitor givinostat stalls colorectal cancer growth by upregulating miR-1938 to suppress ADAM12, with no systemic ...
Tag: tumor suppressor
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Hidden RNA Molecule GAS5 Acts as a Brake on Liver Cancer Growth
A new study shows that the long non-coding RNA GAS5 suppresses hepatocellular carcinoma by sponging miR-18a-5p and restoring the tumor-suppressive ...
Master Switch PRDM1 Steers Natural Killer Cell Maturation and Cancer Defense
A new review details how the transcriptional repressor PRDM1 orchestrates natural killer cell maturation, effector function, and tumor suppression, with ...
Tiny Gene Regulators Show Promise Against the Deadliest Childhood Brain Tumors
New research shows that restoring the microRNAs miR-34a and miR-34c suppresses the survival, migration, invasion, and stemness of pediatric grade ...
Circular RNA Revealed as Hidden Brake on Colorectal Cancer Growth
Researchers report that the circular RNA circMTCL1, sharply depleted in colorectal cancer tumors, suppresses cancer cell growth by sponging miR-145-5p, ...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
RNA-Binding Protein ADAR2 Throttles Bladder Cancer Spread by Destroying Fat-Making Enzyme Message
A new study shows that the RNA-binding protein ADAR2 suppresses bladder cancer metastasis by destabilizing FASN mRNA and curbing fatty ...
Lost tumor brake found to rewire liver cancer cell power plants
Researchers report that loss of the tumor suppressor LZTR1 stabilizes mitochondrial transcription factor A, reprogramming liver cancer cells toward complex ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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