RPL22 Mutations May Shape Drug Sensitivity in Aggressive Endometrial Cancer
Researchers found RPL22 mutations in 42% of undifferentiated/dedifferentiated endometrial carcinoma samples and showed in cell and xenograft models that the ...
Tag: tumor suppressor
Silenced Gene PRSS33 Reactivates Antitumor Immunity in Myelodysplastic Syndromes
Researchers found that the epigenetically silenced gene PRSS33 acts as a tumor suppressor and endogenous inducer of immunogenic cell death ...
GNAZ Slows Lung Cancer Growth by Triggering KIF11 Destruction and Boosts Osimertinib Response
New research in Cell & Bioscience shows that the G-protein subunit GNAZ suppresses lung adenocarcinoma by promoting HUWE1-mediated degradation of ...
Low CEBPD Expression Tied to Poor Breast Cancer Survival, Study Finds
Researchers report that the adipogenesis-related gene CEBPD is downregulated in breast tumors, serves as an independent prognostic indicator of survival, ...
p53 Reverses Bcl-2’s Pro-Survival Grip by Restoring MAM Function in Skin Cancer
New research in Cell Division shows that Bcl-2 overexpression promotes survival of cutaneous squamous cell carcinoma cells by altering mitochondria-associated ...
Hexokinase 2 drives colorectal cancer malignancy by triggering ZNF366 protein degradation
A new study reports that hexokinase 2 promotes malignant phenotypes in colorectal cancer by enhancing UBE3A-dependent ubiquitination and degradation of ...
STAM protein suppresses kidney cancer through a dual EGFR and AKT mechanism
New preclinical research shows the STAM protein suppresses clear cell renal cell carcinoma by inactivating EGFR and degrading AKT, inducing ...
Molecular glue RPT04402 stabilizes tumor-suppressing PP2A protein in lung and uterine cancer studies
University of Michigan researchers report that the molecular glue RPT04402 stabilizes the trimeric tumor suppressor PP2A, shrinking KRAS-mutant lung tumors ...
Givinostat blocks colorectal cancer growth by silencing ADAM12 through miR-1938
New research shows the HDAC inhibitor givinostat stalls colorectal cancer growth by upregulating miR-1938 to suppress ADAM12, with no systemic ...
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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