Tight Junction Protein Revealed as Hidden Brake on Kidney Cancer Growth
Researchers report that the tumor-suppressive protein TJP2 stabilizes TIMM21, which boosts SPRY4 and dampens ERK1/2 signaling to restrain clear cell ...
Tag: tumor suppressor
Lactate Tags a Tumor Suppressor and Fuels Liver Cancer Growth
Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function ...
MicroRNA Drop and CDK7 Signal Offer New Clues for Breast Cancer Diagnosis
A new study finds that the tumor-suppressive microRNA miR-199a-3p is significantly depleted in breast cancer tissue and that combining its ...
Single RNA Letter Swap Turns a Thyroid microRNA From Tumor Suppressor Into Cancer Driver
Researchers show that ADAR2-mediated A-to-I RNA editing switches miR-376a-3p from a tumor suppressor to an oncogene in papillary thyroid cancer ...
Single-Cell Atlas of Glioma Reveals Astrocyte Gene TTYH1 as a Hidden Tumor Suppressor
An integrated single-cell and spatial multi-omics study of glioma identifies the astrocyte-associated gene TTYH1 as a tumor suppressor that impedes ...
How Losing p53 Lets Mutant Cells Colonize Healthy Tissue: A Wnt Gradient Revealed
A Mount Sinai study published in Science shows that loss of the tumor suppressor p53 reorganizes Wnt signaling into a ...
Viral Saboteur Unmasked: How EBV Silences a Key Immune Molecule to Drive Nasopharyngeal Cancer
A new review in Cancer Immunology, Immunotherapy details how EBV-encoded miR-BART4 suppresses the innate immune molecule BPIFB1/LPLUNC1, whose loss promotes ...
Zinc Finger Protein ZNF154 Pushes Bladder Cancer Cells Into Ferroptosis by Suppressing a Key Survival Pathway
Researchers show that the zinc finger protein ZNF154 suppresses bladder cancer by activating PTEN transcription, blocking PI3K/AKT signaling, and triggering ...
Lost Epigenetic Guardian CBX7 Emerges as Key Driver and Drug Target in Glioblastoma
A new review shows that the epigenetic regulator CBX7 acts as a tumor suppressor in glioblastoma, and that restoring its ...
Mitochondrial Enzyme SUCLG2 Emerges as a Tumor Suppressor in Colorectal Cancer
Researchers found that the mitochondrial enzyme SUCLG2 suppresses colorectal cancer by lowering SAM levels to demethylate GADD45G and reactivate p53-mediated ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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