3D-Printed Melanoma Models Promise Better Drug Tests but Face an Analysis Bottleneck
A new perspective highlights that while 3D bioprinted melanoma models closely mimic real tumors, outdated two-dimensional analysis methods are undermining ...
Tag: tumor microenvironment
AI-Powered Map of Glioblastoma Reveals Tumor Ecosystem States and Immune Programs
A machine-learning-assisted reanalysis of single-cell and bulk transcriptomic data provides a reproducible framework for characterizing glioblastoma ecosystem states while carefully ...
FAPI-Conjugated Nanoparticles Show Promise for Targeted Cancer Imaging and Therapy
A systematic review finds that nanoparticles conjugated with fibroblast activation protein inhibitors show strong preclinical promise for targeted cancer imaging ...
How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off
New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...
Light-based therapy triggers immune cure of thick pigmented melanoma in mice
A dual-photosensitizer light treatment combined with optical clearing eradicated thick pigmented melanoma in mice by triggering a potent, long-lasting anti-tumor ...
Cancer Protein LGALS3BP Reshapes the Cargo of Neuroblastoma Extracellular Vesicles
New research links the secreted glycoprotein LGALS3BP to selective enrichment of microRNAs and the RNA-binding protein SRSF1 in neuroblastoma extracellular ...
Cancer’s Hidden Architects: Scientists Map the Bacterial Ecosystem Living Inside Oral Tumors
A pilot study from the University of Palermo used 16S rRNA sequencing to reveal that oral squamous cell carcinoma tumors ...
Guided missiles of cancer medicine: how antibody-drug conjugates are rewriting targeted therapy
A comprehensive Molecular Cancer review explains how antibody-drug conjugates deliver lethal payloads to tumors, why resistance emerges, and which next-generation ...
Human 3D Tumor Assembloids Reveal How Targeted Interferon-Gamma Therapies Could Outsmart the Tumor Microenvironment
Roche researchers validate a human 3D immune-containing colorectal cancer assembloid platform that captures interferon-gamma signaling, uncovers fibroblast plasticity, and demonstrates ...
Cancer Cells Run on a Metabolic Hybrid Engine, and Surgeons May Soon Map It
A new review argues that cancer cells toggle between glycolysis and mitochondrial respiration in hybrid metabolic states, and that mapping ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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