Neutrophils Disable NK Cells to Fuel Breast Cancer Liver Metastasis
A mouse study finds that neutrophils in breast cancer liver metastases suppress NK cell killing by contact-dependent downregulation of Eomes ...
Tag: tumor microenvironment
Gene Screens in Aged Mice Reveal Two Distinct Routes to Restore Tumor-Fighting T Cells
Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...
RNA Methylation Enzyme NSUN2 Keeps Lung Tumors Cold and Blocks Immunotherapy
A new study reports that the RNA m5C methyltransferase NSUN2 suppresses CCL5-driven CD8+ T cell recruitment in lung adenocarcinoma through ...
Platelets and neutrophils build premetastatic niches that nanotherapies may intercept
A new review describes how platelet–neutrophil crosstalk and NETosis create premetastatic niches and outlines nanotherapeutic strategies for early anti-metastatic intervention.
TTC39B emerges as a pan-cancer prognostic marker suppressing renal cancer cell growth
A pan-cancer analysis links TTC39B expression to prognosis and tumor immunity across 33 cancer types, with experiments showing the gene ...
Single-cell atlas maps immune and metabolic shifts in testicular mixed tumors
A new single-cell transcriptomic atlas of testicular mixed germ cell tumors identifies 13 major cell types, m6A machinery upregulation and ...
Two Cytokines May Team Up to Drive Cancer Pain, Review Argues
A new review proposes that TNF-α and IL-6 act as a self-amplifying inflammatory axis in cancer pain, while stressing that ...
New Protocol Tracks Natural Killer Cells Attacking Tumors in 3D, One Cell at a Time
A newly published protocol details a three-component tumor organoid co-culture system with 3D live-cell imaging that quantifies single-cell dynamics of ...
Systematic Review Maps How Honey Compounds Might Complement Liver Cancer Therapy
A systematic review of preclinical studies suggests honey and its flavonoids show anti-hepatocellular carcinoma mechanisms, though no rigorous human trials ...
Bone marrow stromal cells drive IL-6 metabolic rewiring and bortezomib resistance in multiple myeloma
Bone marrow stromal cells drive interleukin-6-mediated metabolic reprogramming and bortezomib resistance in multiple myeloma, a new open-access study reports.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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