Tag: tumor immunology

A circular RNA derived from the PIAS1 gene encodes a previously unknown 108-amino-acid protein that colon cancer cells use to ...

Single-cell RNA sequencing of post-chemotherapy AML bone marrow has identified five macrophage polarization states whose abundance tracks with treatment response ...

Researchers have developed fourth-generation CAR T cells targeting mucin 1 that show superior proliferation, reduced exhaustion, and enhanced tumor-killing activity ...

Spatial transcriptomic mapping of liver tumors has revealed that CCL19-producing fibroblasts recruit CXCR3-positive B cells to form an antitumor axis ...

A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...

New research shows that T cell responses against endogenous retroviral peptides, particularly murine leukemia virus fragments, are critical for checkpoint ...

A comprehensive atlas of STING mutations consolidates genetic, structural, and clinical data to clarify how variants drive autoinflammation, immunodeficiency, and ...

Researchers at University Hospital Tübingen have engineered NG2-targeting bispecific antibodies that redirect T cells to kill melanoma cells, with a ...

A retrospective study of 195 colorectal cancer patients found that removing twenty or more tumor-draining lymph nodes after neoadjuvant immunotherapy ...

New research shows that activating bystander T cells inside tumors triggers antigen-independent tumor killing through cytokines, nitric oxide and innate ...