RBM15 Drives Non-Small Cell Lung Cancer Immune Evasion via RNA Methylation
Researchers have demonstrated that the RNA methyltransferase subunit RBM15 drives immune evasion in non-small cell lung cancer cell models by ...
Tag: tumor immunology
Combinatorial Post-Translational Modifications Dynamically Regulate p53 Activity in Cancer
A literature review in Advanced Cancer Research reveals that a dynamic network of post-translational modifications orchestrates p53 activity, mutant stability, ...
New Mouse Culture System Produces Over One Billion Pure cDC1 Immune Cells
A 23-day bone marrow culture protocol generates roughly 1.5 billion high-purity CD103-positive cDC1 immune cells from a single mouse.
Radiation Exposes Targetable Glutamine Transport Weakness in Triple-Negative Breast Cancer
A preclinical study shows that ionizing radiation induces a transient glutamine dependency in triple-negative breast cancer that can be targeted ...
Single-Cell Analysis Maps Immunosuppressive Ecosystems and CD274 Signaling in Myelodysplastic Syndromes
Computational single-cell transcriptomics and in vitro validation reveal eleven distinct bone marrow immune states and complex CD274 communication networks in ...
Perforin Kills Cancer Cells Alone, Without Granzymes, Study Finds
New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...
ZG16 Overexpression Curbs Colorectal Cancer Cell Growth and Boosts Macrophage Phagocytosis in Lab Tests
ZG16 overexpression in SW620 colorectal cancer cells suppressed proliferation, migration and invasion, induced apoptosis, reduced CD47 and CD24 expression, and ...
Neutrophils Disable NK Cells to Fuel Breast Cancer Liver Metastasis
A mouse study finds that neutrophils in breast cancer liver metastases suppress NK cell killing by contact-dependent downregulation of Eomes ...
BRD4 emerges as key regulator of STING expression in cancer cells
BET inhibition suppresses STING expression at its promoter and enhancer regions, weakening the immune response triggered by PARP inhibitors.
CT83 Protein Marks Triple-Negative Breast Cancer, but Its Aggressive Links Prove Indirect
A study of 222 breast cancer patients found CT83 expression in nearly half of tumors, with its ties to aggressive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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