Platelets Caught Sabotaging Cancer-Killing Immune Cells Through a Single Molecular Handshake
New research shows that activated platelets bind CD8-positive T cells via P-selectin and PSGL-1, directly suppressing their tumor-killing activity and ...
Tag: tumor immunology
Gut Microbe Transplants May Reverse Immunotherapy Resistance in Liver Cancer
A phase II pilot trial found that a single fecal microbiota transplantation combined with atezolizumab and bevacizumab was safe and ...
Rare Hormone-Spewing Adrenal Tumors Rewire Their Own Cells and Immune Neighborhood, Single-Cell Map Reveals
A single-cell RNA sequencing study has revealed that rare ACTH- and CRH-secreting pheochromocytomas harbor a primitive Schwann cell precursor-like tumor ...
Liver Cancer Gene GNG4 Found to Build Walls That Keep Immune Cells Out of Tumors
New research links the gene GNG4 in malignant liver cells to tumor immune exclusion and reduced CD8-positive T cell infiltration ...
Smoking May Shorten Colorectal Cancer Survival Most in Tumors With Low LINE-1 Methylation
A prospective cohort study of 1,208 colorectal cancer patients finds that current smoking is linked to substantially worse survival only ...
Miniature Brain Tumors in a Dish Offer New Hope for Beating Immunotherapy Resistance
A new review in the Journal of Translational Medicine describes how brain tumor organoid platforms are being used to reconstruct ...
Cancer Protein TIPE Hijacks Immune Cells to Fuel Colorectal Tumor Growth
New research reveals how the tumor protein TIPE drives colorectal cancer progression by converting macrophages into tumor-supporting M2 cells through ...
Chemotherapy Found to Supercharge Cancer Vaccines When Timed Just Right
Researchers at Ludwig Oxford have discovered that chemotherapy regimens such as CarboTaxol can act as adjuvants that dramatically boost cancer ...
Scientists Uncover Why a Key Antitumor T Cell Loses Its Fight in Ovarian Cancer
A new study links CEACAM1 expression and dysregulated SHP-1, LCK, and ZAP70 signaling to the functional exhaustion of follicular cytotoxic ...
Hidden Protein From Circular RNA Shields Colon Cancer Cells From Fiery Death
A circular RNA derived from the PIAS1 gene encodes a previously unknown 108-amino-acid protein that colon cancer cells use to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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