Lactylation gene signature predicts outcomes in clear cell renal cell carcinoma
A machine-learning 15-gene lactylation signature predicts prognosis and drug response in clear cell renal cell carcinoma, with CCNA2 identified as ...
Tag: tumor immune microenvironment
Therapy-induced senescence reshapes the tumor immune microenvironment, review argues
A review in Molecular Biology Reports examines how therapy-induced senescence and the SASP reshape the tumor immune microenvironment, and how ...
Eight-Gene Signature Ties Immune Landscape to Gastric Cancer Survival
An integrated transcriptomic and tissue-level study links an eight-gene risk score and the immune regulator RGS1 to survival in gastric ...
B7-H3 blockade and MEK inhibition overcome immune defenses in prostate cancer models
In preclinical castration-resistant prostate cancer models, combining B7-H3 blockade with the MEK inhibitor trametinib overcame compensatory immune suppression and structural ...
OSBPL3 Shapes Colorectal Cancer Progression Through Gut Microbes and Immune Microenvironment
New research links the lipid-binding protein OSBPL3 to colorectal cancer progression, gut microbiota shifts, and immune microenvironment changes, with two ...
Chemotherapy disrupts immune structures in Epstein-Barr virus-linked gastric cancer
Epstein-Barr virus-associated gastric cancer (EBVaGC) has long been regarded as the most immunologically favorable form of a disease that remains ...
BRCA Mutations Shape Immune Landscapes in Ovarian Cancer, Spatial Study Finds
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
Research report: JAK-STAT signaling: a key mechanism of immune microenvironment remodeling in breast cancer and novel strategies for targeted therapy
A 2026 review finds that JAK-STAT signaling suppresses antitumor immunity in breast cancer, but mixed clinical trial results expose challenges ...
Small spatial-transcriptomics study links metabolism to T-cell exclusion in esophageal adenocarcinoma
A small clinical study linked lipid metabolism and mitochondrial respiration to low CD8-positive T-cell infiltration in esophageal adenocarcinoma using spatial ...
Myeloid drugs rarely prove immune conversion in solid tumors
A 2026 narrative review finds that most myeloid-directed cancer programs show target activity without proving immune conversion and proposes a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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