Cysteine Dependence Reveals Metabolic Weakness in Small Cell Lung Cancer
Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...
Tag: tumor heterogeneity
BRCA Mutations Shape Immune Landscapes in Ovarian Cancer, Spatial Study Finds
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
Five Aptamers Show Activity Against Triple-Negative Breast Cancer Cells
A five-aptamer panel reduced tumor-cell viability, proliferation, migration and colony formation in several triple-negative breast cancer cell lines, with variable ...
Commentary frames tumor microenvironment as a driver of metastasis and resistance
A 2026 commentary proposes that metabolic plasticity, stromal reprogramming and immune-metabolic competition create an adaptive tumor ecosystem that can promote ...
AI Maps Cell-State Gene Networks in Cancer, but Causation Still Requires Experiments
A mini-review finds that AI-assisted reconstruction of cell-state-specific gene regulatory networks can illuminate tumor plasticity and drug resistance, but experimental ...
Spatial epigenomics reveals stromal niche-associated regulatory programs across pancreatic neuroendocrine tumor grades
A combined single-nucleus and spatial ATAC-seq study maps grade-associated chromatin regulatory programs in non-functional pancreatic neuroendocrine tumors, revealing spatially organized ...
EGFR Co-Targeting with Nanocarriers Offers New Precision Path for Triple-Negative Breast Cancer
A new review in Genes & Diseases outlines how co-targeting EGFR alongside other tumor-driving molecules, delivered via nanocarriers, could enable ...
AI Reads Lung CT Scans to Predict Drug Resistance Before Treatment Begins
A Chinese research team combined delta-radiomics from CT scans with clinical data and SHAP-based machine learning interpretation to predict the ...
AI Reads Liver Scans to Predict Which Colorectal Cancer Patients Will Respond to Chemotherapy
Researchers in China have developed an interpretable machine learning model that analyzes all liver metastases on contrast-enhanced CT scans to ...
Two PET scans may outsmart a single biopsy in predicting aggressive neuroendocrine cancer outcomes
A new study shows that discordant lesions on dual-tracer FDG and FAPI PET/CT strongly predict shorter progression-free survival in aggressive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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