Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Tag: tumor evolution
Single-cell atlas reveals how hidden clones drive pancreatic cancer’s deadly evolution
A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
NIH Pioneer Award Backs Scientist Building Cancer Therapies That Evolve Alongside Tumors
NIH has awarded its Director's Pioneer Award to Sylvester Comprehensive Cancer Center virologist Leor Weinberger for developing an evolving oncolytic ...
Single-Cell Map Traces How Prostate Tumors Evolve to Resist Hormone Therapy
A single-cell re-analysis of 44 prostate cancer samples reveals that androgen deprivation therapy transiently activates immune programs within tumor cells ...
Chaperone Blockade Turns a Hidden Stress Protein Into a Target for CAR Immunotherapy
New research shows that blocking the HSP90 chaperone forces stressed tumor cells to display GRP78 on their surface, making drug-resistant ...
New computational tool maps the cell-state crosstalk that decides survival in IDH-mutant glioma
A new computational framework called CSI-TME infers prognostic interactions between cell states in the tumor microenvironment from bulk RNA-seq data, ...
After Nine Years of ALK Drugs, Lung Cancer Switches Gears—and a Second Mutation Saves the Day
A case report documents an ALK-rearranged lung cancer patient who acquired a druggable EGFR L858R mutation after nearly nine years ...
Circular DNA Emerges as an Epigenetic Engine Driving Cancer’s Rapid Adaptation
A new review in Molecular Cancer argues that extrachromosomal DNA acts as a dynamic epigenetic reprogramming platform that reshapes chromatin, ...
Cancer’s Family Tree Gets a Map: Lineage Tracing Reveals How Tumors Grow and Spread
A new Nature Genetics study combines spatial transcriptomics and lineage tracing to map how lung tumor subclones expand, reshape their ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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