Accelerated Biological Aging Links Elevated Plasma Lactate to Liver Disease Risk
A prospective study of 175,612 UK Biobank participants indicates that accelerated biological aging partially mediates the association between elevated circulating ...
Tag: Transcriptomics
Computational Analysis Identifies New Drug Targets for Liver Cancer
A 2026 study in the Egyptian Journal of Medical Human Genetics used transcriptomic and network biology analysis to identify druggable ...
Synovial Stress Genes Track Local Joint Inflammation Rather Than Osteoarthritis Stage
A comprehensive multi-cohort transcriptomic analysis reveals that synovial NRF2-HO-1-GPX4 axis remodeling in knee osteoarthritis is biologically heterogeneous and primarily driven ...
Machine Learning Consensus Tool Identifies Reproducible Biomarkers Across Heterogeneous Transcriptomic Cohorts
Researchers developed TENTACLES, an open-source consensus machine learning framework that extracted reproducible gene signatures across 689 intestinal biopsy samples from ...
Blood Gene Expression Signature Correlates With Low Postmenopausal Bone Density
Researchers identified reproducible osteoclastogenesis gene signatures and validated six candidate genes in whole blood that correlate with postmenopausal bone mineral ...
Oligodendrocytes Show Metabolic Stress in Parkinson’s Disease
New transcriptomic analysis reveals that oligodendrocytes in Parkinson's disease patients exhibit metabolic stress and disrupted communication with neurons.
Polyamine Metabolism Heterogeneity Predicts Outcomes and Immune Interactions in Liver Cancer
A transcriptomic study reveals that polyamine metabolism heterogeneity correlates with poor prognosis and distinct immune microenvironment interactions in hepatocellular carcinoma.
Single-Cell Gene Network Models Identify Disease Mechanisms Across Specific Cell Types
Junha Cha and Insuk Lee review computational frameworks that construct reference-based and de novo cell-type-specific gene networks from single-cell RNA ...
Transcriptomic study prioritizes multicellular mitochondrial signature in murine and human MASLD
An exploratory cross-species transcriptomic analysis prioritized a seven-gene multicellular mitochondrial signature linked to immune and parenchymal features in fatty liver ...
Deep Generative Model Infers Complex Causal Gene Networks in Alzheimer’s Research
Researchers developed DAG-VAERL, a deep generative architecture combining graph attention networks and reinforcement learning to reconstruct causal gene regulatory networks ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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