GATA6 represses BMP2 to restrain lung squamous cell carcinoma
In preclinical lung squamous cell carcinoma models, GATA6 directly represses BMP2, while elevated BMP2 activates ERK1/2 signaling and promotes tumor-cell ...
Tag: transcriptional regulation
STAT3 directly silences Ets-2 to enable IL-2 in activated T cells
A study in Jurkat T cells found that activated STAT3 binds the Ets-2 promoter, reduces expression of a transcriptional silencer, ...
Three WRKY proteins switch on red pigment production in tree peony
Three WRKY transcription factors activate PsDFR2 and promote anthocyanin accumulation, helping explain the molecular basis of red pigmentation in tree ...
Scientists Map the Genetic Switches That Help a Healing Herb Survive Salty Soil
Researchers have catalogued 47 WRKY transcription factor genes in Codonopsis pilosula and linked specific members, including Cpi05G005333-I, to the herb's ...
Hidden BRD4-S Protein Shields Gastric Tumors From Cell Death and Blunts Chemotherapy
A short isoform of the BRD4 protein helps gastric cancer cells resist ferroptotic cell death by sustaining glutathione production, thereby ...
Soybean Gene GmVQ32 Offers New Shield Against Toxic Aluminium and Starving Soils
Researchers at South China Agricultural University report that the soybean VQ motif gene GmVQ32 enhances tolerance to both aluminium toxicity ...
Light, Hunger, and Humidity: The Genetic Switches That Launch a Deadly Crop Pathogen’s Spores
New research reveals how nitrogen starvation, a cryptochrome photoreceptor, and humidity checkpoints govern the transcriptional program that drives spore formation ...
Pine Gene Switch Revealed: PmGRAS8 Boosts Phosphate-Starvation Regulator PmSPX1
Researchers identified the GRAS transcription factor PmGRAS8 as a candidate activator of the phosphate-responsive PmSPX1 promoter in Masson pine, shedding ...
Scientists Uncover a Fat-Metabolism Switch That Fuels Esophageal Cancer and Blunts Chemotherapy
A new study shows that the transcription factor ELF4 activates the enzyme UGT8, reshaping sphingolipid metabolism to drive esophageal squamous ...
Deep Learning Tool Reads Leukemia’s Regulatory Code to Predict Patient Risk
A new deep learning framework called TERfinder integrates multi-omics data to map enhancer-promoter interactions in myeloid leukemia, pinpointing key regulatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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