Sequencing cohorts link genomic features to survival in early-stage lung cancer
A clinical sequencing study associated tumor mutation burden, whole-genome doubling and mutations in four genes with worse survival in early-stage ...
Tag: TP53
Dietary supplement Ca-αKG slows lung tumors in female mice but speeds growth in males, UCLA study finds
A UCLA study found that the dietary supplement calcium alpha-ketoglutarate slowed lung tumor growth in female mice while enlarging tumors ...
Biallelic TP53 alterations linked to severe infections in higher-risk MDS
When a single gene fails twice, the consequences ripple far beyond cancer biology. A new study from The First Affiliated ...
AI Reads CT Scans and Tumor Genetics to Predict Kidney Cancer Outcomes
A CT-based multimodal radiogenomic model combining tumor imaging, perirenal fat features, and genetic data outperformed conventional risk stratification for clear ...
Lactation Drug Cabergoline May Cut Postpartum Breast Cancer Risk, Study Finds
A widely used lactation-suppressing drug, cabergoline, was linked to a sharply lower postpartum breast cancer risk in women and halved ...
Early NOTCH1 Mutation Shields Esophageal Tissue from Turning Cancerous
A new evolutionary analysis shows that NOTCH1 mutations flourish in normal esophageal tissue but epistatically suppress the later driver mutations, ...
Routine Patient Data Reveals Hidden Patterns of Cancer Cachexia in Landmark Study
A landmark analysis of nearly 60,000 cancer patients reveals that cachexia occurs in recurring episodes tied to tumor genetics and ...
AI Maps Whole Gene Networks That Cancers Cannot Live Without
A machine learning framework called BioBombe maps the biological processes that cancers depend on for survival, revealing new vulnerabilities and ...
Cancer Gene Mutations Awaken the Immune System in Early Oral Cancer
Researchers at Tokushima University found that combined TP53 and CDKN2A mutations activate cGAS–STING-mediated antitumor immunity, delaying progression to invasive oral ...
Plant Compound Hecogenin Emerges as Top Computational Candidate Against Epstein–Barr Virus
A computational screen of 1,000 plant compounds identifies the steroidal saponin hecogenin as a leading multitarget inhibitor candidate against Epstein–Barr ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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