Cigarette Smoke Reprograms Lung Stem Cells, Steering Which Cancer Takes Hold
A Johns Hopkins study shows chronic cigarette smoke exposure reprograms distinct lung stem cell populations through epigenetic changes, determining whether ...
Tag: TP53
Hidden p53 Variant Δ246p53 Emerges as a DNA Damage Sentinel Driving Cellular Senescence
Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances ...
Hidden RNA switches reshape cancer proteins and sabotage drug targets
A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...
Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Gene Mutations After Liver Transplantation May Reveal Which Liver Cancer Patients Face Recurrence
Whole-exome sequencing of liver transplant patients with hepatocellular carcinoma has identified a 13-gene mutation signature that independently predicts tumor recurrence ...
Colombian Study Tracks Ten-Year Survival in Breast Cancer Patients Carrying Inherited Risk Variants
A retrospective cohort of 259 Colombian breast cancer patients with germline pathogenic variants found a ten-year overall survival of 75 ...
Blood Cancer Risk After CAR-T and Stem Cell Transplants: Systematic Review Maps Latency and Clonal Drivers
A systematic review of nine studies finds that therapy-related myeloid neoplasms after CAR-T therapy emerge earlier and carry worse survival ...
A Simple Staining Test Predicts Early Return of Colorectal Cancer After Liver Surgery
A pattern-based p53 immunohistochemistry test identified patients with colorectal liver metastases at nearly four times the risk of early cancer ...
Thyroid Cancer After Childhood Cancer: Small Tumors, Surprising Spread, Hidden Genes
A new case series from Beijing Children's Hospital finds that second primary thyroid cancers in childhood cancer survivors present as ...
Mutational Map of Gallbladder Cancer Reveals New Paths to Precision Therapy
A new review maps the recurrent mutations and signaling crosstalk driving gallbladder cancer, identifying ERBB2 and KRAS as hub targets ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!