Tumor protein stratifin blinds NK cells in bile duct cancer
A study in Journal of Translational Medicine shows that the tumor protein stratifin stabilizes PAK1 and activates MYC-driven NECTIN2 expression, ...
Tag: TIGIT
Phase I NK510-PD-1 combination shows preliminary safety in nine lung cancer patients
A nine-patient phase I trial found that TIGIT-disrupted NK510 could be combined with PD-1 blockade without observed dose-limiting toxicities in ...
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Pancreatic Cancer Cells Constantly Rewrite Their DNA to Outsmart Treatment
A single-cell analysis of nearly half a million pancreatic cancer cells shows that continuously evolving clones reshape their DNA to ...
One Dose of a New Immunotherapy Combo Triggered Four Organ Crises in a Lung Cancer Patient
A single cycle of atezolizumab plus tiragolumab triggered simultaneous myocarditis, hepatitis, thrombocytopenia, and dermatomyositis in a lung cancer patient, whose ...
Bladder Cancer Atlas Reveals Drug Targets Switch On and Off as Tumors Mature
A single-cell atlas of 157,449 bladder cancer cells shows that antibody-drug conjugate targets rise and fall along a tumor differentiation ...
Immune Checkpoints on Gamma Delta T Cells Follow Their Own Rules, Study Finds
New research shows that immune checkpoint receptors on human gamma delta T cells are regulated in a lineage- and context-dependent ...
Liver Macrophages Carrying Apolipoprotein E Act as a Molecular Brake That Drives T Cell Exhaustion and Preserves Transplant Tolerance
A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...
New Insights into Immune Checkpoints’ Role in Controlling Inflammation
Immune checkpoints (ICs) have long been recognized as critical regulators of T-cell activity within the tumor microenvironment, acting as inhibitory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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