Kidney Cells Switch On a Cholesterol Program When Flooded by Protein, Study Finds
A donor-aware single-cell analysis links membranous nephropathy to an LXR-linked cholesterol-handling state in kidney tubule cells and reveals a matching ...
Tag: TCGA
New Cancer Framework Ties Epigenetics, DNA Repair and Immunity Into One Immunogenicity Score
A new multi-omics framework proposes that tumor immunogenicity emerges only when epigenetic permissiveness, DNA damage response configuration and immune activation ...
Blood-Borne Immune Checkpoint Proteins Linked to Kidney Cancer Risk in New Case-Control Study
A Chinese case-control study finds that soluble immune checkpoint proteins in the blood, particularly CTLA-4, HVEM and CD28, are significantly ...
Buckwheat Compound Fagopyrine Emerges as Computational Lead for AKT1 Cancer Drug Design
A pan-cancer computational study identified the buckwheat-derived compound fagopyrine as a strong predicted binder to the AKT1 kinase, positioning it ...
Inherited genome rearrangements shape tumor mutation burden in breast and gynecologic cancers
Inherited changes in the architecture of the human genome, far larger than the single-letter mutations that have dominated cancer genetics ...
Blocking FGFR Signaling Supercharges Immunotherapy in Hard-to-Treat Colorectal Cancer
New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade ...
Silencing a Fat-Making Master Switch Pushes Pancreatic Cancer Cells Toward Self-Destruction
New research links elevated SREBF1 expression to lipid metabolism signatures in pancreatic cancer and shows that silencing the gene triggers ...
Scientists Uncover How Oral Cancer Cells Outsmart Cisplatin by Blocking Ferroptosis
New research reveals that the secreted protein DKK1 helps oral squamous cell carcinoma resist cisplatin by keeping the SLC3A2 cystine ...
Telomere-Linked Senescence Genes Predict Survival in Cervical Cancer, Study Finds
A new bioinformatic study in Reproductive Sciences shows that a risk model built from telomere-related senescence genes can independently predict ...
Gut Metabolite Genes Could Predict Colorectal Cancer Survival and Immunotherapy Response
Researchers built a four-gene signature based on propionate metabolism that stratifies colorectal cancer patients by survival risk and links tumor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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