KARI dataset opens multimodal Alzheimer imaging resource for 1,645 adults
The KARI dataset provides 6,217 multimodal imaging acquisitions from 1,645 adults spanning healthy aging, preclinical Alzheimer disease and symptomatic illness.
Tag: tau pathology
Synapses Under Siege: How Plant Compounds May Rebuild the Brain’s Failing Connections in Alzheimer’s Disease
A new review reveals that synaptic failure—not plaque burden—is the strongest driver of Alzheimer's cognitive decline, and plant-derived phytochemicals may ...
Poor Blood Flow to the Brain May Steer Early Tau Pathology Toward Vulnerable Regions
A new mouse study shows that early chronic cerebral hypoperfusion spatially biases tau pathology and drives neuroinflammation at the onset ...
Genes, Big Data and a Protective Mutation Point to New Alzheimer’s Drug Targets
An integrated analysis of human genetics, patient-derived cell models and electronic health records has identified 19 Alzheimer's drug targets in ...
Scientists Rethink Neuronal Senescence as Brain Aging Markers Fail the Test
A new review argues that neurons can acquire senescence-like states in aging and neurodegenerative disease, but peripheral senescence markers cannot ...
New Four-Axis Framework Maps the Hidden Diversity of Atypical Alzheimer’s Disease
A new review proposes a four-axis framework of clinical phenotype, biological context, network topography, and tempo to define the heterogeneity ...
New Hydrophobic Tag Molecule Degrades DAPK1 and Cuts Tau Pathology in Alzheimer’s Mice
Scientists created CJ1, a hydrophobic tagging molecule that selectively destroys the DAPK1 kinase via the proteasome, reducing tau phosphorylation, neurofibrillary ...
Scientists Reveal How Rogue Antibodies Attack the Brain Protein IgLON5
A new structural study reveals how patient autoantibodies recognize the neuronal protein IgLON5, offering a molecular explanation for a rare ...
Brain Protein ATIP Linked to Lower Amyloid Burden in Alzheimer’s Disease
Researchers have found that higher levels of the ATIP protein in postmortem brains of older adults with Alzheimer's disease are ...
Brain-Wide Activity Ties Subcortical Decline to Spreading Tau in Early Alzheimer’s
New research in Nature Communications shows that degeneration in deep subcortical brain regions becomes progressively linked to cortical tau accumulation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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