AI Designs Working T-Cell Receptors That Could Transform Immunotherapy Screening
Researchers have developed a transformer-based AI model that generates functional T-cell receptor sequences tailored to specific epitopes, with laboratory tests ...
Tag: T cell receptor
Immune Cell Resident Gene RBPJ Emerges as Key to Lung Cancer Immunotherapy Success
A new single-cell study identifies the transcription factor RBPJ and CD103-positive tissue-resident memory T cells as central drivers of successful ...
Immune Fingerprints in Blood Reveal Parkinson’s Disease When Patients Are Sorted First
By stratifying Parkinson's patients into mouse-model-anchored immune subtypes, researchers have built T-cell receptor blood tests that exceed 0.8 AUC, overturning ...
Computational Protein Design Supercharges Engineered Immune Cells Against Cancer and Viruses
Researchers at Bar-Ilan University and the Weizmann Institute used computational protein design to create an enhanced T-cell receptor, called SET, ...
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for Resistant Cancers
A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...
Engineered T Cell Receptors With Built-In ICOS Deliver Long-Lasting Anti-Tumor Power
Researchers have engineered T cell receptors fused to the co-stimulatory molecule ICOS, producing T cells that persist longer, resist exhaustion ...
AI Steps In to Rescue Personalized Neoantigen Cancer Vaccines From Costly Guesswork
A new review details how artificial intelligence is being woven into every stage of personalized neoantigen cancer vaccine development, from ...
Chromatin Regulator ANKRD11 Emerges as Switch That Reinvigorates Exhausted T Cells
Researchers have identified ANKRD11 as a chromatin regulator whose loss reprograms CD8+ T cells to fight chronic hepatitis B and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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