Review Reframes cGAS-STING as Context-Sensitive Immune Network Rather Than Simple Switch
A literature review in Medicine Plus indicates that the cGAS-STING pathway operates as a context-dependent signaling network capable of driving ...
Tag: systemic lupus erythematosus
Novel C1QB Variant Causes Functional Complement Deficiency in Lupus Case Study
Researchers identified a novel homozygous C1QB variant causing functional complement deficiency alongside a somatic TNFAIP3 variant in a pediatric lupus ...
Review Evaluates VEGF Signaling Pathways and Targeted Therapies Across Rheumatic Diseases
A comprehensive scientific review outlines how vascular endothelial growth factor signaling drives angiogenesis, immune activation, and tissue remodeling across major ...
Discordant ESR and CRP Tests Do Not Exclude Active Rheumatic Disease
A systematic review of 70 studies reveals that discordant ESR and CRP results stem largely from measurement conventions and timing, ...
Modulating Transposable Genetic Elements Emerges as Dual Strategy Across Diverse Diseases
Researchers evaluate how suppressing or reactivating repetitive genetic elements could treat inflammatory diseases, aging syndromes, and treatment-resistant cancers.
Copied Clinical One-Liners Can Anchor Physicians to Erroneous Diagnoses, Viewpoint Warns
A viewpoint in the Journal of General Internal Medicine highlights how copied patient one-liners can introduce anchoring bias and perpetuate ...
Systematic Review Details Treatments for Severe Lupus Heart and Lung Complications
A systematic review of 67 studies examines immunosuppressive and targeted therapies for inflammatory cardiopulmonary manifestations in systemic lupus erythematosus.
Diagnostic Delays Drive Severe Lupus Damage Across Sub-Saharan Africa Review Finds
A scoping review reveals that structural diagnostic delays and systemic barriers drive high organ damage and mortality in Sub-Saharan African ...
Integrated Human Cell Atlas Uncovers Conserved Multicellular Ecosystems Across Diverse Diseases
Researchers developed PANGEA, an integrated transcriptomic atlas profiling 46.5 million cells across 160 diseases, revealing shared multicellular responses and spatial ...
Hypoxia Drives Lupus Severity by Triggering MARCH5-Mediated FSP1 Degradation in Neutrophils
Researchers found that low oxygen accelerates lupus pathology in mice by prompting the ubiquitin ligase MARCH5 to degrade the ferroptosis ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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