Rotenone-induced Parkinsonism in mice reverses within a year
A 12-month longitudinal study finds that Parkinson-like motor deficits and dopaminergic pathology caused by chronic rotenone exposure in mice fully ...
Tag: substantia nigra
AAV gene replacement restores Parkin pathway activity in preclinical tests
An AAV carrying functional human PRKN restored mitochondrial-pathway signaling in Parkin-deficient cells and patient fibroblasts, while rodent tests showed that ...
Landmark Study Reveals How Cellular Recycling Falters in Parkinson’s Disease
A new study reveals that impaired proteasome function, driven by SUMOylation, may underlie the toxic accumulation of alpha-synuclein in Parkinson's ...
Astrocyte Gene ATP13A2 Revealed as a Hidden Brake on Brain Inflammation in Parkinson’s Disease
New research shows that the Parkinson's-linked gene ATP13A2 keeps astrocytic mitochondria in balance, and that its loss triggers excessive mitochondrial ...
Shared Molecular Fingerprint of Alzheimer’s and Lewy Body Dementia Revealed in Human Brain Maps
A whole-transcriptome study of five brain regions from verified Alzheimer's and Lewy body dementia donors reveals a shared molecular signature ...
Brain Immune Cells Nibble Away Parkinson’s Protein Clumps to Shield Vulnerable Neurons
University of Oxford researchers have discovered that a specialised population of human microglia protects dopamine neurons in Parkinson's disease by ...
Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...
Antioxidant Protein Thioredoxin-1 Reshapes Oligodendrocyte Lineage Cells in Parkinson’s Model
A new study shows that the antioxidant protein thioredoxin-1 regulates the expansion of oligodendrocyte lineage cells and the accumulation of ...
Where the Brain Mislabels the Ordinary: New Map Pinpoints Salience Gone Wrong in Schizophrenia
A large resting-state fMRI study shows that aberrant sensory salience in schizophrenia is tied to reversed connectivity between the ventral ...
Human GLUD2 Gene Variant Worsens Parkinson’s Disease by Igniting an Astrocyte–Microglia Complement Cascade
A human-specific GLUD2 gene variant worsens Parkinson's disease pathology in mice by driving complement C3 signaling from astrocytes to microglia, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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