Anionic Additive Helps Peptide Carriers Release siRNA and CRISPR Cargo Inside Cells
A study of arginine/tryptophan peptides shows that strong carrier-cargo binding blocks gene silencing, and adding a negatively charged component restores ...
Tag: STAT3
STK39 Emerges as a Molecular Clue in Moyamoya Disease Under Hypoxic Stress
A new study links the kinase gene STK39 to endothelial dysfunction and inflammatory activation under hypoxic conditions in moyamoya disease, ...
Targeted Biologics Show Promise for Severe Allergy in Rare Genetic Immune Disorders
A new systematic review of 172 patients finds that dupilumab, omalizumab, and JAK inhibitors can meaningfully control severe atopic disease ...
Engineered Nanobody Drug Tames Inflammation by Rewiring IL-10 Receptor Geometry
Scientists have engineered a tetravalent nanobody agonist that harnesses differential TYK2 dependence and receptor abundance to deliver IL-10's anti-inflammatory power ...
Placental Hormone GDF15 Emerges as Key Driver of Fetal Growth and Potential Therapy
New research in mice and pigs shows that the placental hormone GDF15 drives fetal growth by activating a STAT3-IGF2 signaling ...
Chromatin Architect Satb1 Reveals a Switch That Disarms Tumor-Protective Immune Cells
New research shows the chromatin organizer Satb1 enables regulatory T cells to promote tumor growth while remaining dispensable for preventing ...
Dual-Target Antibody Strikes Two Inflammatory Pathways to Ease Colitis in Mice
Scientists have engineered a bispecific antibody that simultaneously blocks TL1A and IL-12/23p40, suppressing pathogenic Th1/Th17 immune responses and significantly ameliorating ...
Scientists Uncover How Oral Cancer Cells Outsmart Cisplatin by Blocking Ferroptosis
New research reveals that the secreted protein DKK1 helps oral squamous cell carcinoma resist cisplatin by keeping the SLC3A2 cystine ...
Tiny Stem Cell Vesicles Loaded with miR-124 Strike Dual Targets to Curb Colorectal Cancer
Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking ...
Telomerase Enzyme Emerges as a Drug Target for Healing the Brain After Stroke
New research shows that the telomerase enzyme TERT drives neural repair after stroke and that the herbal compound cycloastragenol can ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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