How a Shifting Cast of Transcription Factors Rewires Androgen Signaling in the Aging Brain
New research shows that Alzheimer's disease disrupts androgen receptor signaling in the male brain by dismantling the collaborative transcription factor ...
Tag: STAT3
Peanut Root Compound Shows Promise Against Inflammation-Driven Bile Duct Cancer
A Thai research team reports that an arachidin-rich extract from peanut hairy root cultures suppresses inflammation-driven molecular events linked to ...
Aging Rewires Neutrophils Across the Body, Single-Cell Map Reveals
A single-cell atlas of eight mouse organs shows that aging expands immature, inflammatory neutrophil states that may help drive senescence ...
Hidden Molecular Switch Links H. pylori Infection to Aggressive Gastric Cancer
A new study reveals how the ONECUT2-YOD1-STAT3-PD-L1 signaling axis drives malignant progression and immune evasion in H. pylori-associated gastric cancer.
Traditional Chinese Capsule Fights Arterial Plaque by Reshaping Gut Microbes in Mice
A traditional Chinese medicine capsule reduced atherosclerotic plaques in mice by reshaping gut bacteria, redirecting arachidonic acid metabolism and shifting ...
Plant-Derived Compounds Could Crack Osteosarcoma’s Chemotherapy Resistance by Triggering Ferroptosis
A new review in Molecular Diversity maps how plant-derived natural products can induce iron-dependent ferroptosis and remodel the immune microenvironment ...
Immune checkpoint VSIR fuels gastric cancer growth by amplifying AXL signaling
New research in iScience reveals that the immune checkpoint molecule VSIR drives gastric cancer progression by transcriptionally activating and post-translationally ...
RNA Methylation Enzyme METTL3 Shields the Aging Ear from Inflammatory Damage
New research shows that the RNA methyltransferase METTL3 protects against age-related hearing loss by stabilizing NFKBIA mRNA through m6A modification ...
Vitamin D Compound Tames Psoriasis by Switching Off a Hidden Inflammatory Gene
New research reveals that calcitriol, the active form of vitamin D, suppresses psoriatic inflammation and keratinocyte hyperproliferation by downregulating the ...
Two Ways to Read a Cell’s Master Switches Reveal Hidden Biases in Gene Regulation Studies
A systematic comparison shows that ATAC-seq and multiplexed reporter assays capture distinct, complementary aspects of transcription factor activity, with each ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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