Dexmedetomidine Curbs Chemotherapy-Related Heart Fibrosis in Mouse Study
A mouse and cell study finds dexmedetomidine reduces doxorubicin- and trastuzumab-induced myocardial fibrosis by promoting Serpine1 and regulating the STAT3/Notch-1 ...
Tag: STAT3
Formononetin From Traditional Chinese Formula Shows Preclinical Activity Against Colorectal Cancer
A preclinical study reports that formononetin from Jianpi Tongluo Formula suppresses colorectal cancer progression by inhibiting M2 tumor-associated macrophage polarization ...
Mutant STAT3 protein traps its normal counterpart to drive inherited immunodeficiency
Researchers have shown that a mutant STAT3 protein causes autosomal dominant hyper-IgE syndrome by binding the normal STAT3 protein and ...
Tree Root Compound Shows Weak Lung Cancer Activity but Multitarget Docking Promise
Chemists isolated five dammarane-type triterpenoids from Indonesian Aglaia cucullata roots and found shoreic acid, reported from the species for the ...
Obesity May Harm Sperm Motility Through a STAT3/MTND4 Mitochondrial Pathway in Mice
A mouse and cell study reports that STAT3 transcriptionally activates MTND4, driving ROS production and mitochondrial dysfunction linked to obesity-related ...
Macrophages, Fibroblasts and Cancer Cells Conspire to Switch On a Tumor-Fueling Protein in Pancreatic Cancer
A new study shows that cooperative signals from macrophages, stellate cells and cancer cells switch on the tumor-promoting protein CHI3L1 ...
STAT3 Emerges as Central Switch Behind Failed Cardioprotection in Diabetic Hearts
A new review argues that diabetes-induced dysfunction of the signaling protein STAT3 explains why ischemic conditioning strategies fail to protect ...
Erianin curbs prostate cancer growth in mice and dampens STAT3 signaling
Preclinical experiments found that erianin reduced prostate cancer cell activity and mouse tumor growth while lowering phosphorylation of the STAT3 ...
Smoke lowers RNA methylation enzyme WTAP, stabilizing pIgR to curb lung inflammation in mice
A mouse and cell study finds that smoke inhalation lowers the m6A methyltransferase WTAP, which stabilizes pIgR messenger RNA and ...
IL-35 Cytokine Restores Obesity-Damaged Vessels via STAT3-MAPK/ERK-eNOS Axis
The anti-inflammatory cytokine IL-35 reverses obesity-impaired vasodilation in mice and human endothelial cells by activating the STAT3-MAPK/ERK-eNOS axis, restoring eNOS ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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