Spatial Hi-C Maps 3D Genome Folding Directly Inside Brain Tissue
A new microfluidic method called spatial Hi-C maps genome-wide 3D chromatin folding directly within intact brain tissue sections, revealing lobule-specific ...
Tag: Spatial transcriptomics
NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Ancient Herbal Formulas May Hold the Key to Unlocking Immunotherapy for Hard-to-Treat Colorectal Cancer
A new review proposes that standardized Traditional Chinese Medicine formulas could re-engineer the gut microbiome, myeloid cells, and tumor cell ...
Threaded Microneedles Deliver mRNA and Drugs to Precise Skin Layers
A modular threaded microneedle system delivers a senescence-fighting hydrogel to the dermis and metabolism-restoring mRNA nanoparticles to subcutaneous fat, reversing ...
Dual-Branch AI Framework CrossBranch Sharpens Cell-Type Maps Across Omics Data
A new dual-branch deep learning framework called CrossBranch improves the estimation of cell-type composition from bulk, proteomic, and spatial omics ...
New AI framework DePass cleans and merges multi-omics data across cells and tissues
Researchers have developed DePass, a dual-enhanced graph learning framework that iteratively denoises and integrates paired multi-omics data across single-cell and ...
AI Counts Tumor Buds in Colon Cancer Slides, Offering a New Prognostic Edge
A semi-supervised deep learning system called TBMNet accurately quantifies tumor budding in colorectal cancer slides and reveals molecularly distinct budding ...
New AI tool maps single cells onto tissue space with unprecedented precision
A new deep learning framework called SCmapST uses a seeded matches strategy to map single-cell gene expression data onto spatial ...
Melanoma’s Genetic Blueprint Builds Immune-Proof Tumor Neighborhoods, Study Finds
Researchers at NYU Grossman School of Medicine show that loss of the NF1 tumor suppressor reorganizes melanoma tumors into immunosuppressive ...
Cancer Cells Defy Quiescence Doctrine as MYC Drives a Proliferative Chemoresistance Program
A sweeping integrated genomics study reveals that chemotherapy-resistant tumors across multiple cancer types share a hyperproliferative, MYC-driven state, identifying the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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