New Open-Source Tool Hunts Ultra-Rare Cancer DNA Fingerprints in Blood
Researchers in Groningen developed MNVista, an open-source Bayesian tool that detects multi-nucleotide variants in sequencing data to identify circulating tumor ...
Tag: somatic hypermutation
Why One Antibody Rules Them All: Epistasis Blocks Broad Flu Protection
Deep mutational scanning of the CR9114 antibody reveals that epistasis and pleiotropy make cross-reactive breadth against both influenza A and ...
Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
New research in Nature shows that the histone readers MLLT1 and MLLT3 license the antibody-mutating enzyme AID at specific genomic ...
Somatic Mutations Widen the Reach of Public Antibodies Against SARS-CoV-2 Variants
New research shows that introducing specific somatic hypermutations into IGHV3-53/3-66 public antibodies can dramatically expand their ability to neutralize emerging ...
mRNA flu vaccine sustains germinal centers to broaden antibody responses, study finds
A Korea University-led clinical study found that an mRNA influenza vaccine sustained germinal-center activity for up to six months in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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