Targeted Tumor Irradiation Controls Localized CAR-T Cell Release of TNF
Engineered CAR-T cells equipped with a synthetic radiation-inducible promoter locally release tumor necrosis factor upon tumor irradiation to enhance antitumor ...
Tag: solid tumors
Review Identifies ATG5 as Context-Dependent Switch in Cancer Drug Resistance
A scientific review published in Cancer Cell International highlights ATG5 as a context-dependent molecular switch driving therapy resistance and survival ...
Cancer cells flood tumors with palmitate that exhausts CAR-T cells
Researchers report that the epigenetic regulator BAZ2A drives renal cancer cells to accumulate palmitic acid, which impairs CAR-T cell mitochondria ...
Engineered IL-6-Responsive CAR Macrophages Boost CAR-T Cell Activity Against Solid Tumors
Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.
CAR-NK Cells Move From Concept Toward Clinic as Review Maps Engineering Fixes
A new review synthesizes engineering strategies and early clinical findings for CAR-NK cell immunotherapy in blood cancers and solid tumors.
Ascites metabolism differs sharply depending on tumor cells
A prospective metabolomic study of 35 patients with solid tumors found that ascites fluid shows distinct metabolic profiles depending on ...
Cancer genome profiling uncovers hidden inherited cancer risk in one in ten patients
A prospective trial found constitutional pathogenic variants in about 10 percent of solid tumor patients screened through comprehensive cancer genome ...
Preclinical thyroid cancer study restores CAR-T target with targeted drugs
A preclinical Mayo Clinic study found that MAPK inhibitors restored TSHR on anaplastic thyroid cancer cells and improved tumor control ...
Preclinical plug-and-play CAR T cells can be reconfigured after treatment
An animal study by City of Hope researchers shows that modular CAR T cells can accept engineered adaptors after treatment, ...
Adaptive sampling brings rapid whole-genome profiling to pediatric cancer diagnosis
Canadian researchers report that a single Oxford Nanopore whole-genome sequencing assay with adaptive sampling detected fusion genes, small variants, copy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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