Intraperitoneal Infusion Improves CAR-T Cell Therapy in Solid Tumor Models
In solid tumor models, intraperitoneal infusion improved CAR-T cell antitumor efficacy and persistence compared to standard intravenous delivery.
Tag: solid tumors
Study Analyzes Pediatric Major Illness Patterns and Healthcare Disparities Across China
A spatial analysis of 13,112 platform-reported pediatric major-disease cases in mainland China reveals pronounced regional clustering, healthcare resource inequalities, and ...
MASCC and CISNE Show Similar Mortality Prediction in Stable Febrile Neutropenia
A prospective emergency department cohort study found that MASCC and CISNE scores had comparable discrimination for 30- and 90-day mortality ...
Review Synthesizes Musashi-2 Mechanisms in Post-Transcriptional Disease Regulation
A scientific review highlights Musashi-2 as a context-dependent post-transcriptional organizer involved in stabilizing pathological cellular states across diverse diseases.
Targeted Tumor Irradiation Controls Localized CAR-T Cell Release of TNF
Engineered CAR-T cells equipped with a synthetic radiation-inducible promoter locally release tumor necrosis factor upon tumor irradiation to enhance antitumor ...
Review Identifies ATG5 as Context-Dependent Switch in Cancer Drug Resistance
A scientific review published in Cancer Cell International highlights ATG5 as a context-dependent molecular switch driving therapy resistance and survival ...
Cancer cells flood tumors with palmitate that exhausts CAR-T cells
Researchers report that the epigenetic regulator BAZ2A drives renal cancer cells to accumulate palmitic acid, which impairs CAR-T cell mitochondria ...
Engineered IL-6-Responsive CAR Macrophages Boost CAR-T Cell Activity Against Solid Tumors
Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.
CAR-NK Cells Move From Concept Toward Clinic as Review Maps Engineering Fixes
A new review synthesizes engineering strategies and early clinical findings for CAR-NK cell immunotherapy in blood cancers and solid tumors.
Ascites metabolism differs sharply depending on tumor cells
A prospective metabolomic study of 35 patients with solid tumors found that ascites fluid shows distinct metabolic profiles depending on ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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