313TE targets IL-13Rα2-positive tumors in preclinical testing
A preclinical study reports that the IL-13E13Y-based T-cell engager 313TE linked IL-13Rα2-positive tumor cells to T cells, promoting receptor-dependent killing ...
Tag: solid tumors
First DS1025 dose administered in international Phase 1 solid-tumor trial
Kansai Medical University Hospital gave the first worldwide dose of investigational CD25-directed antibody drug conjugate DS1025 in a global Phase ...
MSIPep prioritizes tumor peptides in leukemia and solid-tumor datasets
MSIPep combines immunopeptidomics, transcriptomics and deep learning to identify and computationally prioritize candidate tumor peptides in leukemia and solid-tumor datasets.
Myeloid drugs rarely prove immune conversion in solid tumors
A 2026 narrative review finds that most myeloid-directed cancer programs show target activity without proving immune conversion and proposes a ...
Big Data Cancer Biomarker Studies Advance Discovery but Await Clinical Validation
Eleven studies using machine learning, single-cell profiling, imaging, liquid biopsy and clinical data identify candidate cancer biomarkers, but retrospective designs ...
Autophagy’s Context-Dependent Roles Shape Solid-Tumor Treatment Strategies
A 2026 collection of five reviews and one small tissue-expression study shows that autophagy can restrain or support solid tumors ...
Single-Cell Sequencing Extends Tumor Analysis to Fixed Clinical Samples
A Roche-led benchmark found that the 10X Genomics GEM-X Flex assay with chop-fix processing improves single-cell RNA profiling of frozen ...
Antibody–Drug Conjugates Reshape Solid Tumor Therapy Amid Safety and Target Challenges
A new review in Holistic Integrative Oncology charts the rapid rise of antibody–drug conjugates in solid tumors while detailing the ...
Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy
St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...
HIV-Linked Blood Cancers Strike Younger Patients and Cut Survival, Single-Center Study Finds
A retrospective cohort study of 166 people living with HIV finds that hematologic malignancies strike younger patients, track with high ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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