Turning Off a Cancer Cell’s Survival Switch: How NRF2 Controls Ferroptosis in Targeted Therapy
A new review details how the NRF2 transcription factor shields cancer cells from iron-dependent ferroptotic death and how natural and ...
Tag: SLC7A11
Hidden BRD4-S Protein Shields Gastric Tumors From Cell Death and Blunts Chemotherapy
A short isoform of the BRD4 protein helps gastric cancer cells resist ferroptotic cell death by sustaining glutathione production, thereby ...
Sulphur-handling genes track colorectal cancer molecular subtypes across seven cohorts
A multicohort transcriptomic analysis shows that a predefined 14-gene sulphur-handling programme is reproducibly linked to colorectal cancer consensus molecular subtypes, ...
Plant Compound Acteoside Shields Retinal Cells From Sugar-Driven Ferroptosis by Switching On NRF2
New research shows the plant compound acteoside protects retinal pigment epithelial cells and diabetic mouse retinae from iron-dependent ferroptotic damage ...
PET tracer lights up ferroptosis to track liver cancer immunotherapy in real time
Researchers combined anti-PD-L1 immunotherapy with the PARP inhibitor Olaparib to trigger ferroptosis in liver cancer and used the SLC7A11-targeted PET ...
Astrocyte Redox Switch Linked to Synapse Damage in Multiple Sclerosis
A new single-cell and animal study links SLC7A11-high astrocyte states to antioxidant failure and synaptic remodeling in multiple sclerosis, pointing ...
Iron and Copper Cell Death Pathways May Hold Key to Beating Immunotherapy Resistance
A new review in Medical Oncology argues that simultaneously inducing the iron-driven cell death ferroptosis and the copper-driven cuproptosis, tuned ...
Gut Metabolite 2,8-Dihydroxyquinoline Shields Sperm Cells From Iron-Driven Cell Death
A gut microbiota-derived antioxidant metabolite, 2,8-dihydroxyquinoline, reverses oligoasthenozoospermia in mice by binding the kinase MAPK14 and blocking ferroptotic death of ...
Iron-Powered Cell Death Emerges as Double-Edged Sword in Cancer’s Microenvironment
A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...
A Tiny Dose of Radiation Could Stop Cancer From Spreading to the Liver
A single 2 Gy prophylactic dose of liver radiation reprograms hepatic immune cells via an SAA1–TLR2–CXCL10 signaling axis to recruit ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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