Fungal wilt pathogen’s epigenetic toolkit mapped in first genome-wide HDAC survey
A genome-wide study has identified 11 histone deacetylase genes in Fusarium oxysporum, revealing how the devastating wilt pathogen uses epigenetic ...
Tag: sirtuins
SIRT2: The NAD-Dependent Enzyme That Ties Metabolism to Aging
A new review highlights how the NAD+-dependent deacetylase SIRT2 regulates glucose, lipid, and mitochondrial metabolism while influencing inflammation, genome stability, ...
Tiny Cellular Shuttles Drive Aging in Chronic Lung Disease, Review Finds
A new review in the Chinese Medical Journal details how extracellular vesicles spread cellular senescence across chronic lung diseases and ...
How Stressed Blood Flow and Metabolism Drive Ageing Arteries
A new review proposes that disturbed blood flow and metabolic stress converge to drive endothelial cell senescence, amplifying cardiometabolic vascular ...
Blood NAD+ Levels Track With Frailty in Older Adults, Japanese Study Finds
A cross-sectional study of 529 community-dwelling older adults in Tokyo found that lower whole-blood NAD+ concentrations were associated with higher ...
Melatonin’s Healing Power May Run Through One Ancient Longevity Enzyme
A new review argues that the sleep hormone melatonin exerts many of its protective effects across the heart, kidney, liver, ...
Hibernating Hamsters Rewrite Their Histones, Not Their DNA, to Survive Winter
A new study of Syrian hamster liver shows that facultative hibernation is accompanied by dynamic changes in histone lysine acetylation ...
USP22 Keeps Aging Stem Cells Young by Stabilizing Key Bone-Building Protein
New research reveals that the deubiquitinase USP22 protects bone marrow stem cells from oxidative stress-induced senescence by stabilizing the transcription ...
SIRT1 Silences Jumping Genes by Stabilizing Heterochromatin Complexes
Researchers report that SIRT1 suppresses L1 retrotransposon activity by recruiting and stabilizing the heterochromatin factors Lamin B1 and KAP1, an ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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