PLPP4 marks a fibroblast subset that fuels tumor growth through excess matrix deposition
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via ...
Tag: Single-Cell RNA Sequencing
Immune-cell study hints IL-1β macrophages may fuel pro-tumor signals in liver cancer
Single-cell and multi-omics analyses of hepatocellular carcinoma point to IL-1β-positive macrophages and IL-1R1-positive inflammatory fibroblasts as putative drivers of a ...
Culture Medium Rewrites Drug Sensitivity in Patient-Derived Tumor Organoids
A new study shows that the choice between Wnt-based and OncoPro culture medium reshapes the transcriptional state and drug sensitivity ...
Thyroid Hormone Carrier TTR Pushes Young Brain Stem Cells Toward Differentiation in Mice
A mouse study finds that exogenous transthyretin shifts postnatal subventricular zone progenitors toward differentiated states through pathways that partially converge ...
CXCR4 emerges as a dermal immune signal hub in psoriasis, single-cell and spatial study finds
An integrated single-cell and spatial transcriptomics study finds CXCR4 concentrated in dermal immune cells of psoriatic skin and identifies a ...
Engineered T-BET Pushes Lab-Grown NK Cells Toward Inflammation, Not Full Maturity
Forcing T-BET expression in iPSC-derived NK cells boosted IFN gamma and inflammatory chemokines but left cytotoxic function and terminal maturation ...
Tumor cell program tied to lymphatic responses in aggressive thyroid cancer
A multi-omics study links an extracellular matrix-associated epithelial state and a SERPINA1–SOX4–FN1 molecular axis to lymphatic endothelial responses in papillary ...
Single-cell atlas reveals inflammatory monocyte state tied to WTAP in healthy lungs and COPD
A single-cell atlas of healthy and COPD lung tissue identifies an HSPA1B-positive inflammatory monocyte state whose transcriptional program is associated ...
Machine Learning Study Links ENTPD5 to Radioresistance in Liver Cancer
An integrated machine-learning and single-cell study identifies ENTPD5 as a context-dependent candidate marker of radioresistance in hepatocellular carcinoma, with prognostic ...
Single-cell map reveals immune-fibrotic imbalance driving COPD
A single-cell RNA sequencing analysis of 101,009 cells identifies 17 cell subtypes and reveals reduced macrophage and fibroblast signaling alongside ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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