EGFR feedback blockade boosts pan-RAS inhibitor RMC-6236 in cholangiocarcinoma models
Preclinical work shows the pan-RAS inhibitor RMC-6236 triggers adaptive EGFR feedback in KRAS-mutant cholangiocarcinoma cells, and pairing it with cetuximab ...
Tag: Single-Cell RNA Sequencing
Bladder Cancer Gene Signature Holds Up Across Two Large Cohorts
A reanalysis of two independent bladder cancer cohorts found 4,102 genes with concordant tumor-associated expression changes and confirmed five candidates ...
Serotonin Receptor in Brain Macrophages Boosts Debris Clearance After Stroke
A mouse and human study identifies an Htr2b-positive macrophage subset in the ischemic brain whose serotonin-driven lysosomal activity supports debris ...
New AI framework scDECA fuses gene priors with cell-level structure in single-cell data
Researchers have introduced scDECA, a dual-encoder cross-attention framework that combines raw gene expression, pretrained gene priors and local structure to ...
Gut Microbiome Gene Score Predicts Rheumatoid Arthritis Drug Response in New Study
A computational study built a gut microbiota–metabolite–host gene score that stratified rheumatoid arthritis patients into two molecular subtypes and predicted ...
Tumor Protein RNF128 Linked to Immune Resistance in Bladder Cancer
A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.
Research report: Integrative transcriptomic and single-cell analyses link ENO1 to CD4+ T cell function and glycolysis-associated metabolism in systemic lupus erythematosus
An integrative analysis of bulk and single-cell transcriptomic data identifies ENO1 as a reproducibly upregulated metabolic factor associated with CD4+ ...
Gene Signature Tied to Folate Metabolism Predicts Liver Cancer Survival Unevenly
A 20-gene folate metabolism signature predicted hepatocellular carcinoma survival in some cohorts but failed in another, and the glutathione synthetase ...
New mouse tool targets microvascular endothelial cells in muscle and fat
Scientists have created a CTRP9-CreERT2 knock-in mouse line whose tamoxifen-inducible reporter selectively labels microvascular endothelial cells in heart, skeletal muscle, ...
Endothelial TXNIP emerges as a driver of pulmonary vascular remodeling
A new study reports that inhibiting the protein TXNIP in pulmonary vascular endothelial cells attenuates pulmonary hypertension and vascular remodeling ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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