Smooth Muscle Cells Take Center Stage as Gene Study Reveals New Clues to Pulmonary Hypertension
By merging bulk and single-cell RNA sequencing with machine learning and lab experiments, researchers have identified smooth muscle cells as ...
Tag: Single-Cell RNA Sequencing
Single Gene Emerges as Hidden Link Between Oxygen Starvation and Neuron Death in Parkinson’s Disease
A multi-omics study identifies the mitochondrial pyruvate carrier gene MPC2 as a causal link between hypoxia, mitochondrial energy failure, and ...
Tire Chemicals Linked to Heart Rhythm Disorder in Landmark Study
An integrative study links the tire-derived pollutants 6PPD and 6PPD-quinone to molecular signatures and increased susceptibility of atrial fibrillation through ...
Single-cell atlas reveals how hidden clones drive pancreatic cancer’s deadly evolution
A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...
Embryonic Origin Rewires a RUNX2-MicroRNA Circuit That Decides Which Skull Sutures Heal
A new study shows that embryonic lineage identity, encoded through mitochondrial dynamics and epigenetic silencing of CDK8, determines why blocking ...
Brain Immune Cells Nibble Away Parkinson’s Protein Clumps to Shield Vulnerable Neurons
University of Oxford researchers have discovered that a specialised population of human microglia protects dopamine neurons in Parkinson's disease by ...
Single-Cell Atlas Reveals DLL3 as a Drug Target in Aggressive Cervical Cancer
A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...
Gut Microbe and Its Fatty Acid Break the Inflammatory Loop That Drives Obesity
A cross-species study shows that the gut bacterium Clostridium butyricum and its metabolite butyrate alleviate obesity by disrupting an LPS-EGR1 ...
Aging Fibroblasts Fuel Ovarian Cancer Growth Through a Single Secreted Protein
New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...
Tumor Protein LRG1 Hijacks Neutrophil Mitochondria to Fuel Dangerous Vessel Growth in Bladder Cancer
New research in Advanced Science reveals that the secreted protein LRG1 drives pathological angiogenesis in bladder cancer by binding ANXA2 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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