Machine Learning Links a Rare Protein Modification and Mast Cells to Duchenne Muscular Dystrophy
A new multi-omics and machine learning study identifies the USP18 gene as a hub linking isonicotinylation and mast cell activity ...
Tag: Single-Cell RNA Sequencing
Kidney Cells Switch On a Cholesterol Program When Flooded by Protein, Study Finds
A donor-aware single-cell analysis links membranous nephropathy to an LXR-linked cholesterol-handling state in kidney tubule cells and reveals a matching ...
Lost Genetic Brakes Push Immune Cells Into an Interferon State Seen in Eczema Patients
Researchers in Tokyo engineered a tracking system for Foxp3-deficient regulatory T cells and found that combined loss of Foxp3 and ...
Male hormones speed skin cell turnover while female skin heals faster, study finds
Long-term live imaging of mouse skin reveals that epidermal stem cells feed a transit-amplifying hierarchy whose turnover speed and coordination ...
Single-Cell Study Reveals Three Distinct Fates of Macrophages Infected by Gammaherpesvirus
A single-cell RNA sequencing study of murine gammaherpesvirus 68 reveals that macrophage infection can follow three distinct outcomes, a restricted ...
One Cell Type Rebuilds a Whole Mouse Embryo, From Blastocyst to Beating Heart
Researchers generated mouse embryo models entirely from chemically induced totipotent-like stem cells that self-organized through gastrulation, blood formation and beating ...
Inflammasome Biomarkers Could Predict Which Wounds Heal and Which Turn Chronic
A new review argues that inflammasome-derived molecular biomarkers could predict wound outcomes, distinguish healing from chronic inflammation, and guide precision ...
Human Antibody Factories Reveal a Hidden Scaffold Named Caveolin-1β
Single-cell transcriptomics and proteomics have revealed that human plasma cells selectively express a non-caveolar Caveolin-1β isoform induced by XBP1, positioning ...
Immune Cells That Attack the Heart: Multi-Omics Study Reveals Signature of Checkpoint Inhibitor Myocarditis
A multi-omics study identifies ISG15-positive CD8 T cells and a CCL2-CCR2-mediated inflammatory loop as drivers of immune checkpoint inhibitor-induced myocarditis, ...
Hidden RNA Switches: New Tool Reveals lncRNAs That Define Tumor-Fighting T Cells
A new computational framework called SDSGI uncovers subtype-specific long non-coding RNAs in tumor-infiltrating CD8-positive T cells across multiple cancer types, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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