Single-Cell Map of Gut Chromatin Reveals Which Cells Drive Crohn’s Disease Risk
A single-cell chromatin accessibility atlas of the human intestine maps regulatory programs across 29 cell types and shows that Crohn's ...
Tag: single-cell ATAC-seq
Enhancers That Free Stalled Polymerase Drive Tumor-Feeding Macrophages Across Cancers
A pan-cancer single-cell epigenetic study reveals that tumor-supportive macrophages arise through distinct enhancer-driven trajectories in which releasing paused RNA polymerase ...
New AI Tool MANTRA Reads Leukemia Data in Multiple Dimensions to Reveal Hidden Patient Subgroups
A new Bayesian framework called MANTRA jointly analyzes three-dimensional drug-response data and two-dimensional gene expression matrices, revealing clinically relevant leukemia ...
Single-cell maps reveal how enhancers regulate their target genes
Genomic dark matter has long been the paradox at the heart of human genetics. The vast majority of disease-associated DNA ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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