Norrin complex structure guides potent engineered signaling surrogates
A structural study shows how Norrin, FZD4, TSPAN12 and LRP5 assemble, enabling engineered surrogate proteins with enhanced signaling potency.
Tag: signal transduction
EGFR Co-Targeting with Nanocarriers Offers New Precision Path for Triple-Negative Breast Cancer
A new review in Genes & Diseases outlines how co-targeting EGFR alongside other tumor-driving molecules, delivered via nanocarriers, could enable ...
Bacteria and yeast talk: engineered pheromone link opens new biotech channels
Researchers have engineered Bacillus subtilis to secrete yeast mating pheromone, triggering a fluorescent response in Saccharomyces cerevisiae and establishing the ...
Hidden RNA Molecule Drives Ovarian Cancer Growth by Activating Key Stress Pathway
Researchers found that the long non-coding RNA ATP6V1B1-AS1 promotes ovarian cancer growth and metastasis by binding MAP3K3 and activating the ...
Battery electrolyte that feels dendrites coming before disaster strikes
Researchers in Beijing have created a composite solid electrolyte that converts dendrite penetration into a detectable voltage signal, allowing smart ...
Beyond the On-Off Switch: Chemical Tags on KRAS Reshape Cancer Drug Design
A new review in Advanced Cancer Research details how post-translational modifications regulate KRAS localization, activity, stability, and degradation, opening fresh ...
Plant Alkaloid Narciclasine Shows Promise Against Aggressive Childhood Cancer in Lab Study
A new laboratory study shows that the Amaryllidaceae plant alkaloid narciclasine suppresses the proliferation, migration, and survival of neuroblastoma cells ...
Tyrosine Phosphorylation Pioneer Tony Hunter Wins 2026 Albany Prize
Salk Institute scientist Tony Hunter has been awarded the 2026 Albany Prize in Medicine and Biomedical Research for his 1979 ...
Tetraspanin Protein Supercharges CAR-T Cells by Amplifying IL-2 Signaling
Researchers report that the membrane protein TSPAN32 enhances CAR-T cell potency by assembling the IL-2 receptor complex and amplifying intracellular ...
Dual PI3K/mTOR Inhibitor VDC597 Shows Promise Against Canine Lymphoma and Leukemia in Lab Studies
A dual PI3K/mTOR inhibitor, VDC597, suppresses signaling, kills canine lymphoma and leukemia cells in vitro, and synergizes with dexamethasone, according ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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