Common RT–qPCR Artifact May Inflate RNA Knockdown in CRISPR Experiments
New research shows that a pervasive RT–qPCR artifact can artificially inflate reported RNA knockdown by RNA-targeting CRISPR systems.
Tag: RNA therapeutics
AI Language Model Learns the Grammar of RNA Sequences
A self-supervised language model called NucleicBERT offers researchers a new computational lens on the vast and poorly charted space of ...
Long Noncoding RNAs Emerge as a Shared Language Between Hosts and Pathogens
A Cell Research commentary highlights how long noncoding RNAs mediate regulatory communication between hosts and pathogens across kingdoms, reshaping infection ...
Charge-Switching Lipids Make Lipid Nanoparticles Safer for Gene Delivery
Newly developed charge-switching S-lipids keep lipid nanoparticles neutral in circulation but cationic inside acidic endosomes, enabling nucleic acid delivery with ...
Densely Modified RNA Guides Push Prime Editing to Nearly 70% Efficiency in Living Mice
Scientists have engineered densely chemically modified guide RNAs that boost prime editing efficiency in the mouse liver to nearly 70 ...
Efficient Protein Production via Internal Cap-Initiated Translation
In the rapidly evolving field of RNA therapeutics, circular messenger RNAs (circRNAs) have emerged as promising candidates due to their ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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