ZNF469 Regulates Amino Acid Metabolism to Support Collagen Production in Fibrosis
Researchers show that the zinc-finger protein ZNF469 coordinates amino acid transport and precursor biosynthesis to support collagen production in multi-organ ...
Tag: RNA sequencing
Promoter Hypermethylation Downregulates LncRNA HAND2-AS1 in Bladder Cancer Models
Promoter hypermethylation suppresses the long non-coding RNA HAND2-AS1 in bladder cancer, while experimental restoration inhibits tumor growth and activates interferon-related ...
Drosophila Longevity Study Challenges Transposable Element Model of Reduced Male Lifespan
An extensive comparative analysis in three fruit fly species reveals that sex gaps in longevity stem from genetic background interactions ...
Drought-Tolerant Potatoes Protect Photosynthesis and Activate Antioxidant Enzymes Under Water Stress
Comparative physiological and transcriptomic analyses show that drought-tolerant potatoes withstand water deficit through compensatory antioxidant enzyme activation and light-harvesting complex ...
Review Outlines RNA Sequencing Advances in TCR and BCR Repertoire Profiling
A methodological review details how high-throughput sequencing and specialized bioinformatics pipelines extract T-cell and B-cell receptor repertoires to track immune ...
Immuno-PET Imaging Demonstrates Tumor Target Engagement by Antibody BI 765063
A phase I clinical study in four patients with advanced cancer demonstrated that the anti-SIRPα antibody BI 765063 successfully engages ...
Bacterial Lipopolysaccharide Gene Score Predicts Breast Cancer Outcomes in Clinical Cohorts
An eight-gene bacterial lipopolysaccharide risk score predicts breast cancer prognosis and correlates with immune microenvironment remodeling across clinical and genomic ...
Machine Learning Consensus Tool Identifies Reproducible Biomarkers Across Heterogeneous Transcriptomic Cohorts
Researchers developed TENTACLES, an open-source consensus machine learning framework that extracted reproducible gene signatures across 689 intestinal biopsy samples from ...
IPEC-J2 Cells Recapitulate Key Pathway Responses to PEDV Infection in Piglet Jejunum
A cross-model transcriptomic study shows IPEC-J2 cells share core immune pathways with PEDV-infected piglet jejunum despite differences in response magnitude.
Blood Multi-Omics Reveals Shared Genetic Drivers Linking Aortic Stenosis and Diastolic Dysfunction
A multi-omics analysis of peripheral blood from heart failure patients reveals shared genomic variants, downregulated expression signatures, and convergent mechanoinflammatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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