Blocking the Brain’s Cannabis Receptor Repairs Faulty RNA Splicing in Fragile X Mice
A new study in iScience shows that blocking the cannabinoid CB1 receptor with low-dose rimonabant reverses disease-associated alternative splicing defects ...
Tag: RNA-binding proteins
High Blood Sugar Rewrites Pancreatic Cell Chemistry, Driving Stress Granule Buildup in Diabetes
New research shows that diabetes elevates the histone mark H3K4me1 in pancreatic acinar cells, driving stress granule formation under high ...
TDP-43 Rides Multiple Molecular Motors Along Human Axons, Study Reveals
New research in human neurons shows that the ALS-linked RNA-binding protein TDP-43 is transported along axons by a flexible fleet ...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
Estrogen receptor fuels breast cancer growth through an RNA-tagging loop, study finds
New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the ...
RNA-Binding Protein PTBP3 Drives Kidney Scarring in Diabetes, Study Finds
Researchers at Harbin Medical University report that the RNA-binding protein PTBP3 stabilizes SMAD3 mRNA and drives podocyte epithelial-to-mesenchymal transition, and ...
Neurons Use a MicroRNA Factory on the ER to Decide Which Genetic Messages Ride Extracellular Vesicles
New research shows that the TRBP-containing microRNA production complex on the endoplasmic reticulum acts as a sorting hub that loads ...
Molecular Chaperones Keep ALS Protein Droplets From Hardening Into Disease
A new review in BMC Medicine argues that ALS arises when the cellular systems that keep reversible protein condensates from ...
New Computational Tool Links RNA Motifs to the Proteins That Control Splicing
Researchers have developed RNAmotifs 2.0, a computational framework that couples motif discovery with binding and splicing data to identify the ...
Light-Driven Switch Lets Scientists Turn Genes On and Off in the Same Cell
Researchers at HKUST have engineered a bidirectional photoriboswitch that uses a single blue-light input to simultaneously reconstitute one RNA-binding protein ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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