CDKN2A overexpression linked to radioresistance and immunosuppression in colorectal cancer
Colorectal cancer remains one of the world's most formidable health challenges, ranking as the second leading cause of cancer-related mortality ...
Tag: radioresistance
Blocking a Mitochondrial Fission Protein Could Strip Head and Neck Cancers of Radiation Resistance
New research shows that blocking the mitochondrial fission protein DRP1 collapses antioxidant defenses in head and neck squamous cell carcinoma, ...
How Tumors Survive Radiation: Plastic Cells and Tolerant Niches Drive Recurrence
A new review in Molecular Cancer reframes radioresistance as an ecosystem-level phenomenon in which plastic residual tumor cells survive radiation ...
Drug Repurposing Finds IGF1R Inhibitor That Reverses Radioresistance in Head and Neck Cancer
Researchers in Taiwan mapped a 25-microRNA regulatory network driving radioresistance in head and neck cancer and used transcriptome-guided drug repurposing ...
RNA-Binding Protein Switch Could Sensitize Deadly Pancreatic Cancer to Radiation
Researchers in Beijing have identified a PUM2-PAFAH1B1 regulatory axis that triggers ferroptosis and overcomes radioresistance to iodine-125 seed therapy in ...
Radiotherapy Backfires: PD-1-Positive Monocytes Emerge as Hidden Drivers of Treatment Resistance
New research reveals that radiotherapy induces PD-1 expression on tumor-associated monocytes through an adenosine-driven signaling pathway, creating an immunosuppressive cell ...
Viral Saboteur Unmasked: How EBV Silences a Key Immune Molecule to Drive Nasopharyngeal Cancer
A new review in Cancer Immunology, Immunotherapy details how EBV-encoded miR-BART4 suppresses the innate immune molecule BPIFB1/LPLUNC1, whose loss promotes ...
Hidden Protein Trio Helps Cancer Cells Survive Radiation, Study Finds
A newly identified TIMELESS-SIRT1-Ku70 complex promotes assembly of the Ku DNA repair heterodimer, giving cancer cells resistance to radiation and ...
Scientists Reverse Radiotherapy Resistance in Lung Cancer by Rewiring the Immune Microenvironment
New research shows that lung tumors become radioresistant through ATR signaling activation and immune suppression, but innate immune agonists and ...
Motor Protein KIFC1 Fuels Cervical Cancer Radioresistance Through a Splicing-Driven Glycolytic Switch
New research reveals that the motor protein KIFC1 drives cervical cancer radioresistance by shuttling the splicing factor SRSF3 into the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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