New UPLC Method Measures 15 Purine Metabolites in Half the Time
A refined UPLC-PDA technique quantifies 15 biologically relevant purine metabolites in 33 minutes with nanomolar sensitivity, validated in Lesch-Nyhan disease ...
Tag: purine metabolism
Purine Scaffold Powers a New Generation of Drug Candidates Across Cancer and Infectious Disease
A comprehensive review maps how strategic chemical modifications to the purine scaffold yield potent drug candidates against cancer, malaria, drug-resistant ...
Blood Chemistry Reveals Why Nellore Cattle Beat the Heat While Angus Struggle
Untargeted blood metabolomics reveals that heat-tolerant Nellore cattle mount a coordinated, statistically robust metabolic reprogramming under heat stress, while heat-susceptible ...
Urine test reveals hidden chemical signature of muscle injuries in elite footballers
Researchers analyzing urine from 121 elite footballers identified a metabolomic signature of muscle injury, with a cross-validated AUROC of 0.88 ...
Urea cycle metabolite fuels leukemia growth by switching on a purine-recycling enzyme
A new Nature Metabolism study shows that BCR–ABL-driven leukemia cells hijack the urea cycle intermediate argininosuccinate to activate the nucleotidase ...
Castration Reshapes Meat Quality and Muscle Metabolites in Black Tibetan Sheep
A new metabolomics study shows that castration improves water retention, texture, and amino acid and fatty acid levels in Black ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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