Cell Painting Meets Thermal Proteome Profiling to Decode How Drugs Work
Researchers have combined Cell Painting imaging with thermal proteome profiling through protein-protein interaction networks to accurately identify drug targets and ...
Tag: Proteomics
Gut Microbiome and Brain Chemistry Linked in Overlapping Reflux and Bowel Syndrome
A multi-omics study of patients with diarrhea-predominant irritable bowel syndrome and nonerosive reflux disease reveals gut dysbiosis, disrupted serotonin metabolism, ...
How a Decade of Mass Spectrometry Breakthroughs Is Rewriting Stroke Medicine
A comprehensive review charts how data-independent acquisition, ion-mobility mass analyzers, and new bioinformatics transformed ischemic stroke proteomics between 2015 and ...
Laser-Dissected Proteomics Reveals Where Immunity Really Lives in Triple-Negative Breast Tumors
A new spatial proteomics study shows that immune activity in triple-negative breast cancer is concentrated in the tumor stroma rather ...
New Mass Spectrometry Assay Tracks 42 Obesity Biomarkers in a Single Blood Test
Researchers have developed and validated a multiplexed targeted mass spectrometry assay that simultaneously quantifies 42 obesity-associated proteins in human plasma ...
Glycolysis Gene PGAM2 Emerges as Key Driver of Bull Fertility and Testis Size
A multi-omics study of Blcattle Black bulls identifies the glycolytic enzyme PGAM2 as a central hub linking energy metabolism, testicular ...
Old Wax Blocks, New Signals: Phosphoproteomics Adds a Functional Layer to Brain Tumor Diagnostics
Researchers have shown that routine formalin-fixed paraffin-embedded brain tumor tissue yields robust proteomic and phosphoproteomic profiles that recover EGFR-associated signaling ...
Hidden RNA Errors Found at the Synapse in Frontotemporal Dementia
Multi-omic profiling of synaptosomes from C9ORF72-frontotemporal dementia brain and patient-derived neurons reveals widespread synaptic molecular disruption and, for the first ...
Two Molecular Heart Failure Types Revealed by Deep Protein Maps of the Failing Heart
Proteomic and phosphoproteomic profiling of 149 failing human hearts reveals two molecular subgroups of heart failure that cut across clinical ...
Dual-Branch AI Framework CrossBranch Sharpens Cell-Type Maps Across Omics Data
A new dual-branch deep learning framework called CrossBranch improves the estimation of cell-type composition from bulk, proteomic, and spatial omics ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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