Tag: proteasome

A new review in Genes & Diseases maps how arginine methylation and ubiquitination continuously regulate each other to influence cancer ...

New research reveals that a COP1-HY5-ABI5 feedback loop acts as a molecular switch controlling how germinated seedlings pause growth under ...

Researchers show that the proteasome preferentially cleaves proteins in beta-strand regions, and that a machine learning model using only predicted ...

A new study reveals that impaired proteasome function, driven by SUMOylation, may underlie the toxic accumulation of alpha-synuclein in Parkinson's ...

Researchers identified a fish-specific E3 ubiquitin ligase, NHRE3, that suppresses antiviral immunity in grass carp and rare minnows by tagging ...

A naturally occurring short isoform of the androgen receptor, AR-A, dramatically reduces aggregation and toxicity of the mutant protein causing ...

A new review argues that mammalian cells regulate the construction of their proteasomes through layered transcriptional networks and assembly pathways, ...

A seven-protein immunoproteasome signature detected in blood accurately diagnosed ARDS in clinical cohorts, while blocking the subunit PSMB8 reduced lung ...

Scientists created CJ1, a hydrophobic tagging molecule that selectively destroys the DAPK1 kinase via the proteasome, reducing tau phosphorylation, neurofibrillary ...

A newly identified micropeptide called PKM2 AP inhibits vascular calcification by acting as a molecular glue that triggers ubiquitin-mediated degradation ...