How Cells Build Their Protein Shredder: New Rules of Proteasome Biogenesis
A new review argues that mammalian cells regulate the construction of their proteasomes through layered transcriptional networks and assembly pathways, ...
Tag: proteasome
Blood Protein Signature and Immune Target Show Promise for Earlier ARDS Diagnosis and Treatment
A seven-protein immunoproteasome signature detected in blood accurately diagnosed ARDS in clinical cohorts, while blocking the subunit PSMB8 reduced lung ...
New Hydrophobic Tag Molecule Degrades DAPK1 and Cuts Tau Pathology in Alzheimer’s Mice
Scientists created CJ1, a hydrophobic tagging molecule that selectively destroys the DAPK1 kinase via the proteasome, reducing tau phosphorylation, neurofibrillary ...
Tiny Micropeptide Blocks Vascular Calcification by Tagging PKM2 for Destruction
A newly identified micropeptide called PKM2 AP inhibits vascular calcification by acting as a molecular glue that triggers ubiquitin-mediated degradation ...
Ufd1 Unfolds Ubiquitin Without ATP to Kick-Start Cdc48/p97 Waste Disposal
A small domain of the cofactor Ufd1 unfolds K48-linked ubiquitin without ATP by cooperatively binding two ubiquitin molecules, providing the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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